Počet záznamů: 1

Mechanisms by Which Human DNA Primase Chooses To Polymerize a Nucleoside Triphosphate

  1. 1.
    0342344 - UOCHB-X 2011 RIV US eng J - Článek v odborném periodiku
    Urban, M. - Joubert, Nicolas - Purse, B. W. - Hocek, Michal - Kuchta, R. D.
    Mechanisms by Which Human DNA Primase Chooses To Polymerize a Nucleoside Triphosphate.
    Biochemistry. Roč. 49, č. 4 (2010), s. 727-735 ISSN 0006-2960
    Grant CEP: GA MŠk LC512; GA AV ČR IAA400550902
    Grant ostatní:NIH(US) GM54194
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: C-nucleosides * DNA polymerase * primase * mechanism
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 3.226, rok: 2010

    We used an extensive series of purine and pyrimidine nucleotide analogues to provide further insights into the mechanism by which primase chooses whether or not to polymerize a NTP. The data demonstrate that human primase strongly depends on Watson-Crick hydrogen bonds for efficient nucleotide polymerization.
    Trvalý link: http://hdl.handle.net/11104/0185100