Počet záznamů: 1

6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents

  1. 1.
    0342338 - UOCHB-X 2011 RIV US eng J - Článek v odborném periodiku
    Nauš, Petr - Pohl, Radek - Votruba, Ivan - Džubák, P. - Hajdúch, M. - Ameral, R. - Birkuš, G. - Wang, T. - Ray, A. S. - Mackman, R. - Cihlar, T. - Hocek, Michal
    6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents.
    Journal of Medicinal Chemistry. Roč. 53, č. 1 (2010), s. 460-470 ISSN 0022-2623
    Grant CEP: GA MŠk 1M0508; GA AV ČR 1QS400550501
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: nucleosides * 7-deazapurines * cross-coupling * cytostatic activity
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 5.207, rok: 2010

    A series of novel 7-deazapurine ribonucleosides bearing an alkyl, aryl or hetaryl group in position 6 and H, F, or Cl atom in position 7 has been prepared and showed to possess significant cytostatic effect in nanomolar concentrations. Intracellular phosphorylation to mono- and triphosphates, and the inhibition of total RNA synthesis was demonstrated in preliminary study of metabolism and mechanism of action studies.
    Trvalý link: http://hdl.handle.net/11104/0185095