Počet záznamů: 1

Temperature dependence of N-methyl-d-aspartate receptor channels and N-methyl-d-aspartate receptor excitatory postsynaptic currents

  1. 1.
    0342116 - FGU-C 2011 RIV GB eng J - Článek v odborném periodiku
    Kořínek, Miroslav - Sedláček, Miloslav - Cais, Ondřej - Dittert, Ivan - Vyklický ml., Ladislav
    Temperature dependence of N-methyl-d-aspartate receptor channels and N-methyl-d-aspartate receptor excitatory postsynaptic currents.
    Neuroscience. Roč. 165, č. 3 (2010), s. 736-748 ISSN 0306-4522
    Grant CEP: GA MŠk(CZ) 1M0517; GA MŠk(CZ) LC554; GA ČR(CZ) GA309/07/0271
    Grant ostatní: EC(XE) LSHM-CT-2007-037765
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: hypothermia * patch-clamp recording
    Kód oboru RIV: ED - Fyziologie
    Impakt faktor: 3.215, rok: 2010

    The article focuses on the problematic of temperature dependence of deactivation of native N-Methyl-D-Aspartate (NMDA) receptors in neuronal cultures and the temperature dependence of excitatory postsynaptic currents mediated by synaptic NMDA receptors in rat cortical slices. Our electrophysiology experiments found that both native as well as synaptic receptors exhibit significantly weaker temperature dependence compared to recombinant GluN1/GluN2B NMDA receptors. Synaptic NMDA receptors have characteristics of receptors with low desensitization (20%). Double exponential time course of NMDA receptor deactivation originates mainly from dissociation of agonist and desensitization
    Trvalý link: http://hdl.handle.net/11104/0184937