Počet záznamů: 1

Sustained deficiency of mitochondrial complex I activity during long periods of survival after seizures induced in immature rats by homocysteic acid

  1. 1.
    0341983 - FGU-C 2011 RIV GB eng J - Článek v odborném periodiku
    Folbergrová, Jaroslava - Ješina, Pavel - Haugvicová, Renata - Lisý, Václav - Houštěk, Josef
    Sustained deficiency of mitochondrial complex I activity during long periods of survival after seizures induced in immature rats by homocysteic acid.
    Neurochemistry International. Roč. 56, č. 3 (2010), s. 394-403 ISSN 0197-0186
    Grant CEP: GA ČR(CZ) GA309/05/2015; GA ČR GA309/08/0292; GA MŠk(CZ) 1M0520
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: homocysteic acid-induced seizures * mitochondrial complex I activity * persisting decrease
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 3.601, rok: 2010

    A marked decrease (cca60 %) of mitochondrial complex I activity (observed during the acute phase of seizures induced in immature rats by homocysteic acid) persists during long periods of survival (up to 5 weeks) following seizures. It is accompanied by significant increase of three mitochondrial markers of oxidative damage. The decrease of complex I activity was substantially reduced by treatment with selected free radical scavengers
    Trvalý link: http://hdl.handle.net/11104/0184816