Počet záznamů: 1

DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway

  1. 1.
    0341479 - MBU-M 2010 RIV GB eng J - Článek v odborném periodiku
    Ullmannová-Benson, Veronika - Guan, M. - Zhou, X. G. - Tripathi, V. - Yang, V. - Zimonjic, D. B. - Popescu, C.
    DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway.
    Leukemia. Roč. 23, č. 2 (2009), s. 383-390 ISSN 0887-6924
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: multiple myeloma * tumor suppressor gene * promoter methylation
    Kód oboru RIV: EC - Imunologie
    Impakt faktor: 8.296, rok: 2009

    DLC1 (deleted in liver cancer 1), a tumor suppressor gene that encodes a RhoGTPase-activating protein, is recurrently downregulated or silenced in various solid tumors and hematological malignancies because of epigenetic modifications or genomic deletion. Here, we identified DLC1 promoter hypermethylation in 43 out of 44 multiple myeloma (MM) cell lines, which resulted in downregulation or silencing of DLC1 in 41 samples
    Trvalý link: http://hdl.handle.net/11104/0184459