Počet záznamů: 1

WT1 expression in peripheral leukocytes of patients with chronic myeloid leukemia serves for the prediction of Imatinib resistance

  1. 1.
    0341448 - MBU-M 2010 RIV SK eng J - Článek v odborném periodiku
    Otahalová, E. - Ullmannová-Benson, Veronika - Klamová, H. - Haškovec, C.
    WT1 expression in peripheral leukocytes of patients with chronic myeloid leukemia serves for the prediction of Imatinib resistance.
    Neoplasma. Roč. 56, č. 5 (2009), s. 393-397 ISSN 0028-2685
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: Imatinib * drug resistance * cml
    Kód oboru RIV: EC - Imunologie
    Impakt faktor: 1.192, rok: 2009

    The determination of patient's resistance to a particular drug contributes to more efficient therapeutical approach. The aim of this study was to evaluate if the responsiveness of Chronic Myeloid Leukemia (CML) patients to Imatinib therapy was predictable from WT1 gene expression in peripheral blood leukocytes. To examine the resistance we implemented an in vitro cultivation of the primary cells of 48 CML patients with Imatinib
    Trvalý link: http://hdl.handle.net/11104/0184440