Počet záznamů: 1

Acquired genetic and functional alterations associated with transforming growth factor beta type I resistance in Hep3B human hepatocellular carcinoma cell line

  1. 1.
    0341415 - MBU-M 2010 RIV US eng J - Článek v odborném periodiku
    Zimonjic, D. B. - Zhou, X. L. - Lee, J. S. - Ullmannová-Benson, Veronika - Tripathi, V. - Thorgeirsson,, S. S. - Popescu,, N. C.
    Acquired genetic and functional alterations associated with transforming growth factor beta type I resistance in Hep3B human hepatocellular carcinoma cell line.
    Journal of Cellular and Molecular Medicine. Roč. 13, č. 9 (2009), s. 3985-3992 ISSN 1582-1838
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: expression profiling * hcc * resistance
    Kód oboru RIV: EC - Imunologie
    Impakt faktor: 5.228, rok: 2009

    During the neoplastic process tumour cells frequently acquire resistance to the antiproliferative signals of transforming growth factor-beta (TGF-beta). Here we examined a human hepatocellular carcinoma cell line (Hep3B-TS) sensitive to TGF-beta signalling, and a derivative line (Hep3B-TR) rendered resistant to TGF-beta by stepwise exposure to TGF-beta(1). Comprehensive molecular cytogenetic analysis revealed that the acquisition of TGF-beta-resistance by Hep3B-TR cells was due to loss of TGF-beta receptor 2 (TGF beta RII) gene
    Trvalý link: http://hdl.handle.net/11104/0184413