Počet záznamů: 1

Acute and chronic effects of antidepressants on the G-protein alpha subunit profiles in vitro and in vivo

  1. 1.
    0341172 - UZFG-Y 2010 RIV SE eng J - Článek v odborném periodiku
    Páv, M. - Kovářů, František - Lisá, Věra - Ondráčková-Zeleničková, P. - Fišerová, Anna - Kovářu, H.
    Acute and chronic effects of antidepressants on the G-protein alpha subunit profiles in vitro and in vivo.
    Neuroendocrinology Letters. Roč. 30, č. 5 (2009), s. 592-598 ISSN 0172-780X
    Grant CEP: GA AV ČR IAA601680801
    Výzkumný záměr: CEZ:AV0Z50450515; CEZ:AV0Z50110509; CEZ:AV0Z50200510
    Klíčová slova: C6 glioma cells * C6 astrocytoma cell line * antidepressant
    Kód oboru RIV: ED - Fyziologie
    Impakt faktor: 1.047, rok: 2009

    Neurochemical studies on the etiopathogenesis of depression are also focusing on the transduction system beyond receptors. Trimeric G-proteins play a crucial role in the transmembrane signalling, signal amplification and intracellular processing. Abnormalities of G-protein levels are observed in subjects with depression, G-protein modulation is considered to play a role in the antidepressant mode of action.
    Trvalý link: http://hdl.handle.net/11104/0184244