Počet záznamů: 1

Cell signalling in CNS and immune system in depression and during antidepressant treatment: focus on glial and natural killer cells

  1. 1.
    0341156 - UZFG-Y 2010 RIV SE eng J - Článek v odborném periodiku
    Kovářu, H. - Páv, M. - Kovářů, František - Raboch, J. - Fišerová, Anna
    Cell signalling in CNS and immune system in depression and during antidepressant treatment: focus on glial and natural killer cells.
    Neuroendocrinology Letters. Roč. 30, č. 4 (2009), s. 421-428 ISSN 0172-780X
    Grant CEP: GA AV ČR IAA601680801
    Výzkumný záměr: CEZ:AV0Z50450515; CEZ:AV0Z50200510
    Klíčová slova: astrocyte * cAMP * depression
    Kód oboru RIV: ED - Fyziologie
    Impakt faktor: 1.047, rok: 2009

    There is a considerable evidence that inflammatory response and immune system changes are the part of depression. Components of cellular immune system natural killer cells, important effectors of immune surveillance, are sensitive to stress response, and their functions are compromised in depressive subjects. Many lines of evidence also point to the loss of both neuronal and glial plasticity and neurotrophic factor support under chronic stress or in depression. There is an increasing knowledge of the role of astrocytic cells in neuroplastic processes and neurotransmitter metabolism. Alterations in the glial populations are observed in major depressive subjects. Antidepressant treatment is modulating glial signalization cascades, increasing production of neurotrophic molecules, supporting neuroplasticity processes, and also modulating functions of natural killers. At the level of membrane signalling, antidepressants show a direct influence upon G alpha subunit levels in both immune system and CNS. These findings support the view that antidepressants influence activity of natural killer and astrocytic populations, and this could be of importance in the depression etiopathogenesis and/or treatment.
    Trvalý link: http://hdl.handle.net/11104/0184231