Počet záznamů: 1

Structure of the motor subunit of type I restriction-modification complex EcoR124I

  1. 1.
    0341137 - UEK-B 2010 RIV US eng J - Článek v odborném periodiku
    Lapkouski, Mikalai
    Structure of the motor subunit of type I restriction-modification complex EcoR124I.
    Nature Structural and Molecular Biology. Roč. 1, č. 16 (2009), s. 94-95 ISSN 1545-9985
    Výzkumný záměr: CEZ:AV0Z60870520
    Klíčová slova: SWI2/SNF2 ATPASE * DNA * ENDONUCLEASE
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 12.273, rok: 2009

    Type I restriction-modification enzymes act as conventional adenine methylases on hemimethylated DNAs, but unmethylated recognition targets induce them to translocate thousands of base pairs before cleaving distant sites nonspecifically. The first crystal structure of a type I motor subunit responsible for translocation and cleavage suggests how the pentameric translocating complex is assembled and provides a structural framework for translocation of duplex DNA by RecA-like ATPase motors.
    Trvalý link: http://hdl.handle.net/11104/0184216