Počet záznamů: 1

Wnt/beta-catenin signaling blockade promotes neuronal induction and dopaminergic differentiation in embryonic stem cells

  1. 1.
    0341089 - BFU-R 2010 RIV US eng J - Článek v odborném periodiku
    Čajánek, L. - Ribeiro, D. - Liste, I. - Parish, C.L. - Bryja, Vítězslav - Arenas, E.
    Wnt/beta-catenin signaling blockade promotes neuronal induction and dopaminergic differentiation in embryonic stem cells.
    Stem Cells. Roč. 27, č. 12 (2009), s. 2917-2927 ISSN 1066-5099
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: embryonic stem cells * Wnt pathway * dopaminergic neurons
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 7.747, rok: 2009

    Embryonic stem cells (ESCs) represent not only a promising source of cells for cell replacement therapy, but also a tool to study the molecular mechanisms underlying cellular signaling and dopaminergic (DA) neuron development. Here we used mouse ESCs (mESCs) lacking Wnt1 or the low-density-lipoprotein receptor-related protein 6 (LRP6) to decipher the action of Wnt/b-catenin signaling on DA neuron development in mESCs.
    Trvalý link: http://hdl.handle.net/11104/0184183