Počet záznamů: 1

Genetic interaction between Lrp6 and Wnt5a during mouse development

  1. 1.
    0341084 - BFU-R 2010 RIV US eng J - Článek v odborném periodiku
    Andersson, E. - Bryjová, Lenka - Biris, K. - Yamaguchi, T.P. - Arenas, E. - Bryja, Vítězslav
    Genetic interaction between Lrp6 and Wnt5a during mouse development.
    Developmental Dynamics. Roč. 239, č. 1 (2010), s. 237-245 ISSN 1058-8388
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: Wnt5a * Lrp6 * somitogenesis
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 2.864, rok: 2010

    Lrp6 is generally described as a receptor required for signal transduction in the Wnt/b-catenin pathway. Wnt5a, however, is a Wnt ligand which usually does not activate Wnt/b-catenin but rather activates non-canonical Wnt signaling. Here we describe phenotypes found in Wnt5a/Lrp6 compound mutant mice, including a worsening of individual Wnt5a or Lrp6 loss of function phenotypes. Lrp6 haploinsufficiency in a Wnt5a-/- background caused spina bifida and exacerbated posterior truncation.
    Trvalý link: http://hdl.handle.net/11104/0184179