Počet záznamů: 1

Enhanced levels of mitochondrial enzyme 17β-hydroxysteroid dehydrogenase type 10 in patients with Azheimer disease and multiple sclerosis

  1. 1.
    0341047 - URE-Y 2010 RIV GB eng J - Článek v odborném periodiku
    Krištofíková, Z. - Bocková, Markéta - Hegnerová, Kateřina - Bartoš, A. - Klaschka, J. - Říčný, J. - Řípová, D. - Homola, Jiří
    Enhanced levels of mitochondrial enzyme 17β-hydroxysteroid dehydrogenase type 10 in patients with Azheimer disease and multiple sclerosis.
    Molecular BioSystems. Roč. 10, č. 5 (2009), s. 1174-1179 ISSN 1742-206X
    Grant CEP: GA MZd NR9322
    Výzkumný záměr: CEZ:AV0Z20670512
    Klíčová slova: 17beta-HSD 10 * Alzheimer disease * SPR sensor
    Kód oboru RIV: JB - Senzory, čidla, měření a regulace
    Impakt faktor: 4.015, rok: 2009

    This paper describes detection of mitochondrial 17-HSD10 enzyme using a surface plasmon resonance (SPR) biosensor and ELISA method. 17-HSD10 enzyme is involved in pathogenesis of Alzheimer disease (AD) and represents a potential target for AD diagnostics. It was demonstrated that the reported SPR biosensor is capable of detecting 17β-HSD10/Aβs complex in CSF samples and it was revealed the patients with AD exhibited elavated levels of 17β-HSD10/Aβs complex compared to the controls.
    Trvalý link: http://hdl.handle.net/11104/0184156