Počet záznamů: 1

Preclinical evaluation of linear HPMA-doxorubicin conjugates with pH-sensitive drug release: Efficacy, safety and immunomodulating activity in murine model

  1. 1.
    0340865 - MBU-M 2010 RIV US eng J - Článek v odborném periodiku
    Šírová, Milada - Mrkvan, Tomáš - Etrych, Tomáš - Chytil, Petr - Rossmann, Pavel - Ibrahimová, Markéta - Kovář, Lubomír - Ulbrich, Karel - Říhová, Blanka
    Preclinical evaluation of linear HPMA-doxorubicin conjugates with pH-sensitive drug release: Efficacy, safety and immunomodulating activity in murine model.
    Pharmaceutical Research. Roč. 27, č. 1 (2010), s. 200-208 ISSN 0724-8741
    Grant CEP: GA AV ČR KAN200200651
    Výzkumný záměr: CEZ:AV0Z50200510; CEZ:AV0Z40500505
    Klíčová slova: immunomodulation * doxorubicin * murine lymphoma
    Kód oboru RIV: EC - Imunologie
    Impakt faktor: 4.456, rok: 2010

    Well-defined linear conjugates of HPMA copolymer and doxorubicin bound via a pH-controlled linkage can induce complete cure of already developed murine solid tumors without significant side effects, and induce development of specific anti-tumor resistance. The HPMA-doxorubicin conjugate is a good candidate for clinical trials
    Trvalý link: http://hdl.handle.net/11104/0005783