Počet záznamů: 1

Dissociation of nystatin and amphotericin analogues: characterization of minor anti-fungal macrolides

  1. 1.
    0340845 - MBU-M 2010 RIV GB eng J - Článek v odborném periodiku
    Ulrych, Aleš - Derrick, P.J. - Adámek, F. - Novák, Petr - Lemr, Karel - Havlíček, Vladimír
    Dissociation of nystatin and amphotericin analogues: characterization of minor anti-fungal macrolides.
    European Journal of Mass Spectrometry. Roč. 16, č. 1 (2010), s. 73-80 ISSN 1469-0667
    Grant CEP: GA MŠk LC07017
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: antibiotics * nystatin * amphotericin
    Kód oboru RIV: EE - Mikrobiologie, virologie
    Impakt faktor: 1.103, rok: 2010

    Tandem mass spectrometry combined with Fourier transform ion cyclotron resonance (FTICR) has been the basis for rationalizing the fragmentation mechanisms of antifungal macrolides nystatin A1, amphotericin B and pimaricin. The positive ion mass spectra were not informative, however, the dissociation of deprotonated molecules led to structurally significant ring-opened fragments. Using this approach of tandem FTICR mass spectrometry (MS/MS) and electrospray ionization (ESI) coupled with high-performance liquid chromatography (HPLC), eleven macrolide natural analogues or degradation products were characterized in the nystatin mixture
    Trvalý link: http://hdl.handle.net/11104/0005782