Počet záznamů: 1

Antioxidant and antiviral activities of silybin fatty acid conjugates

  1. 1.
    0340841 - MBU-M 2011 RIV FR eng J - Článek v odborném periodiku
    Gažák, Radek - Purchartová, Kateřina - Marhol, Petr - Živná, L. - Sedmera, Petr - Valentová, K. - Kato, N. - Matsumura, H. - Kaihatsu, K. - Křen, Vladimír
    Antioxidant and antiviral activities of silybin fatty acid conjugates.
    European Journal of Medicinal Chemistry. Roč. 45, č. 3 (2010), s. 1059-1067 ISSN 0223-5234
    Grant CEP: GA AV ČR KJB400200701; GA MŠk OC08049; GA MŠk(CZ) LC06010
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: Influenza virus * silibinin * silybin
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 3.193, rok: 2010

    wo selective acylation methods for silybin esterification with long-chain fatty acids were developed, yielding a series of silybin 7-O- and 23-O-acyl-derivatives of varying acyl chain lengths. These compounds were tested for their antioxidant (inhibition of lipid peroxidation and DPPH-scavenging) and anti-influenza virus activities. The acyl chain length is an important prerequisite for both biological activities, as they improved with increasing length of the acyl moiety
    Trvalý link: http://hdl.handle.net/11104/0184002