Počet záznamů: 1

The potential of the cruciform structure formation as an important factor influencing p53 sequence-specific binding to natural DNA targets

  1. 1.
    0340614 - BFU-R 2010 RIV GB eng J - Článek v odborném periodiku
    Brázdová Jagelská, Eva - Pivoňková, Hana - Fojta, Miroslav - Brázda, Václav
    The potential of the cruciform structure formation as an important factor influencing p53 sequence-specific binding to natural DNA targets.
    Biochemical and Biophysical Research Communications. Roč. 391, č. 3 (2010), s. 1409-1414 ISSN 0006-291X
    Grant CEP: GA ČR(CZ) GP301/07/P160; GA ČR(CZ) GP204/07/P476; GA AV ČR(CZ) IAA500040701
    Grant ostatní: GA ČR(CZ) GA301/10/1211
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: scDNA * plasmid pBluescript SK * linear DNA
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 2.595, rok: 2010

    P53 binding to DNA is strongly influenced by DNA topology. We investigated the cruciform structure formation of various inverted repeats in p53-responsive sequences from p21, RGC, mdm2 and GAAD45 promoters under negative superhelical stress and analyzed the effects of these DNA topology changes on p53-DNA binding.
    Trvalý link: http://hdl.handle.net/11104/0183823