Počet záznamů: 1

Oxidative damage by carcinogenic polycyclic aromatic hydrocarbons and organic extracts from urban air particulate matter

  1. 1.
    0340206 - UEM-P 2010 RIV NL eng J - Článek v odborném periodiku
    Hanzalová, Kateřina - Rössner ml., Pavel - Šrám, Radim
    Oxidative damage by carcinogenic polycyclic aromatic hydrocarbons and organic extracts from urban air particulate matter.
    Mutation Research - Genetic Toxicology and Environmental Mutagenesis. Roč. 696, č. 2 (2010), s. 114-121 ISSN 1383-5718
    Grant CEP: GA MŠk 2B08005; GA MŽP(CZ) SP/1B3/8/08
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: carcinogenic polycyclic aromatic hydrocarbons * oxidative damage in vitro * extractable organic matter
    Kód oboru RIV: DN - Vliv životního prostředí na zdraví
    Impakt faktor: 2.938, rok: 2010

    The role of oxidative damage in the mechanisms of action of selected individual c-PAHs, an artificial mixture of c-PAHs and extractable organic matter (EOM) from urban air particulate matter was investigated using two cell lines (HepG2 and HEL). The response of the cell lines to the tested compounds differed substantially. The study demonstrated the potency of EOM to induce oxidative damage to DNA, lipids and proteins in HepG2 cells, but not in HEL cels. The analysis also showed that c-PAHs had less ability to cause oxidative damage.
    Trvalý link: http://hdl.handle.net/11104/0183497