Počet záznamů: 1

Glycosyl Azides: Novel Substrates for Enzymatic Transglycosylations

  1. 1.
    0339610 - MBU-M 2010 RIV GB eng M - Část monografie knihy
    Křen, Vladimír - Bojarová, Pavla
    Glycosyl Azides: Novel Substrates for Enzymatic Transglycosylations.
    Practical Methods for Biocatalysis and Biotransformations. Chippenham, Wiltshire: John Wiley and Sons Ltd, 2009 - (Whittall, J.; Sutton, P.), s. 232-235. ISBN 978-0-470-51927-1
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: carbohydrate synthesis * glycosyl donor * glycosidase
    Kód oboru RIV: CE - Biochemie

    Enzymatic transglycosylation catalysed by glycosidases is a respected method in carbohydrate synthesis. The spectrum of acceptors is practically infinite, contrary to glycosyl donors, usually nitrophenyl glycosides. We have developed glycosyl azides as novel, efficient and easily prepared glycosyl donors for glycosidases. Their high water solubility facilitates the synthesis of disaccharides by transglycosylations with comparable or better yields than using traditional O-glycosides. Using the azide moiety, such products can simply be conjugated to complex structures after reduction of the azide to an amine
    Trvalý link: http://hdl.handle.net/11104/0183083