Xanomeline binding to and activation of muscarinic receptors

0339422 - FGÚ 2011 RIV IT eng C - Konferenční příspěvek (zahraniční konf.)
Jakubík, Jan - Machová, Eva - El-Fakahany, E. E. - Doležal, Vladimír
Xanomeline binding to and activation of muscarinic receptors.
New trends in Alzheimer and Parkinson Related Disorders: ADPD 2009. Pianoro: Medimond, 2009 - (Fisher, A.; Hanin, I.), s. 145-148. ISBN 978-88-7587-528-2.
[International Conference Alzheimer´s diseases/Parkinson´s diseases /9./. Praha (CZ), 11.05.2009-15.05.2009]
Grant CEP: GA AV ČR(CZ) IAA500110703; GA ČR GA305/09/0681; GA MŠMT(CZ) LC554
Grant ostatní: EC(XE) LiPiDiDiet 211696
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: xanomeline * muscarinic receptors * signal transduction
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy

Xanomeline binds reversibly to orthosteric binding site and irreversibly to another site of all subtypes of muscarinic receptors. In acute functional assays stimulates only M1/M4 subtypes. We demonstrated that irreversibly bound xanomeline also stimulates M2 receptors in cerebral cortex tissue
Trvalý link: http://hdl.handle.net/11104/0182950