Počet záznamů: 1

Xanomeline binding to and activation of muscarinic receptors

  1. 1.
    0339422 - FGU-C 2011 RIV IT eng C - Konferenční příspěvek (zahraniční konf.)
    Jakubík, Jan - Machová, Eva - El-Fakahany, E. E. - Doležal, Vladimír
    Xanomeline binding to and activation of muscarinic receptors.
    New trends in Alzheimer and Parkinson Related Disorders: ADPD 2009. Pianoro: Medimond, 2009 - (Fisher, A.; Hanin, I.), s. 145-148. ISBN 978-88-7587-528-2.
    [International Conference Alzheimer´s diseases/Parkinson´s diseases /9./. Praha (CZ), 11.05.2009-15.05.2009]
    Grant CEP: GA AV ČR(CZ) IAA500110703; GA ČR GA305/09/0681; GA MŠk(CZ) LC554
    Grant ostatní:EC(XE) LiPiDiDiet 211696
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: xanomeline * muscarinic receptors * signal transduction
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy

    Xanomeline binds reversibly to orthosteric binding site and irreversibly to another site of all subtypes of muscarinic receptors. In acute functional assays stimulates only M1/M4 subtypes. We demonstrated that irreversibly bound xanomeline also stimulates M2 receptors in cerebral cortex tissue
    Trvalý link: http://hdl.handle.net/11104/0182950