Počet záznamů: 1

Sperm antibodies, intra-acrosomal sperm proteins, and cytokines in semen in men from infertile couples

  1. 1.
    0339340 - BTO-N 2010 RIV US eng J - Článek v odborném periodiku
    Ulčová-Gallová, Z. - Gruberová, J. - Vrzalová, J. - Bibková, K. - Pěknicová, Jana - Mičanová, Z. - Topolčan, O.
    Sperm antibodies, intra-acrosomal sperm proteins, and cytokines in semen in men from infertile couples.
    American Journal of Reproductive Immunology. Roč. 61, č. 3 (2009), s. 236-245 ISSN 1046-7408
    Výzkumný záměr: CEZ:AV0Z50520701
    Klíčová slova: intra-acrosomal protein * cytokines * infertility
    Kód oboru RIV: EC - Imunologie
    Impakt faktor: 2.172, rok: 2009

    The aim of this study was to investigate seminal sperm-agglutinating antibodies, intra-acrosomal proteins, sperm head abnormalities, and cytokines in men from infertile couples.The direct mixed anti-immunoglobulin reaction test in semen, and immunocytochemical method using monoclonal antibodies and immunofluorescence for the examination of intra-acrosomal proteins in the spermatozoa were used. Cytokines in seminal plasma were determined by multiplex immunoanalytic xMAP. Sperm-agglutinating antibodiesin seminal plasma were found to be more in astheno- and oligoasthenospermatic men than in normospermatic men. Sperm head pathology and very low amounts of acrosomal proteins were frequently detected in pathologic semen samples. Cytokine levels defined as 'high' were obtained especially for IL-8, IL-5, IL-6,IL-10. The high cellularity in semen was correlated with higher IL-5. Immunologic cause of male infertility is a very important risk factor in the pathogenesis of sperm cells.
    Trvalý link: http://hdl.handle.net/11104/0182895