Počet záznamů: 1

Divergence of allosteric effects of rapacuronium on binding and function of muscarinic receptors

  1. 1.
    0339074 - FGU-C 2010 RIV GB eng J - Článek v odborném periodiku
    Jakubík, Jan - Randáková, Alena - El-Fakahany, E. E. - Doležal, Vladimír
    Divergence of allosteric effects of rapacuronium on binding and function of muscarinic receptors.
    B M C Pharmacology. Roč. 9, č. 15 (2009), s. 1-20 ISSN 1471-2210
    Grant CEP: GA ČR GA305/09/0681; GA MŠk(CZ) LC554; GA AV ČR(CZ) IAA500110703
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: muscarinic receptors * allosteric modulation * rapacuronium
    Kód oboru RIV: ED - Fyziologie

    Albeit rapacuronium decreases affinity of acetylcholine under equilibrium conditions it accelerates acetylcholine binding. This results in potentiation of receptor activation by acetylcholine at low concentrations of rapacuronium. These observations highlight the necessity of performing functional tests under non-equilibrium conditions that resemble physiological conditions
    Trvalý link: http://hdl.handle.net/11104/0182683