Počet záznamů: 1

Mitochondrial K-ATP opening confers protection against lethal myocardial injury and ischaemia-induced arrhythmias in the rat heart via PI3K/Akt-dependent and -independent mechanisms

  1. 1.
    0337058 - FGU-C 2010 RIV CA eng J - Článek v odborném periodiku
    Matejíková, J. - Ravingerová, T. - Pancza, D. - Čarnická, S. - Kolář, František
    Mitochondrial K-ATP opening confers protection against lethal myocardial injury and ischaemia-induced arrhythmias in the rat heart via PI3K/Akt-dependent and -independent mechanisms.
    Canadian Journal of Physiology and Pharmacology. Roč. 87, č. 12 (2009), s. 1055-1062 ISSN 0008-4212
    Grant CEP: GA ČR(CZ) GA305/07/0875; GA MŠk MEB080837
    Grant ostatní: VEGA(SK) 2/0173/08; APVV(SK) SK-CZ-0049-07
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: myocardial ischemia * diazoxide * PI3K/Akt
    Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
    Impakt faktor: 1.341, rok: 2009

    In isolated perfused rat hearts, bracketing of diazoxide (K-ATP opener) with wortmannin (PI3K inhibitor) blunted its infarct size-limiting effect but not the protection against ischemic arrhythmias. It appears, that PI3K/Akt pathway play a positive role of the K-ATP opener against lethal myocardial injury, but it is not involved in suppression of ischemia-induced arrhythmias
    Trvalý link: http://hdl.handle.net/11104/0181146