Počet záznamů: 1

Current and Novel Inhibitors of HIV Protease

  1. 1.
    0336551 - UOCHB-X 2011 RIV CH eng J - Článek v odborném periodiku
    Pokorná, Jana - Machala, L. - Řezáčová, Pavlína - Konvalinka, Jan
    Current and Novel Inhibitors of HIV Protease.
    Viruses. Roč. 1, č. 3 (2009), s. 1209-1239 ISSN 1999-4915
    Grant CEP: GA MŠk 1M0508
    Grant ostatní: GA AV ČR(CZ) IAAX00320901
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: HIV protease * protease inhibitor * HAART
    Kód oboru RIV: CE - Biochemie

    This review describes all nine currently available FDA-approved protease inhibitors, discusses their pharmacokinetic properties, off-target activities, side-effects, and resistance profiles. The compounds in the various stages of clinical development are also introduced, as well as alternative approaches, aiming at other functional domains of HIV PR. The potential of these novel compounds to open new way to the rational drug design of human viruses is critically assessed.
    Trvalý link: http://hdl.handle.net/11104/0180760