Antileukotrienic phenethylamido derivatives of arylalkanoic acids in the treatment of ulcerative colitis

0335377 - MBÚ 2010 RIV FR eng J - Článek v odborném periodiku
Junek, R. - Kverka, Miloslav - Jandera, A. - Panajotová, V. - Šatinský, D. - Macháček, M. - Kuchař, M.
Antileukotrienic phenethylamido derivatives of arylalkanoic acids in the treatment of ulcerative colitis.
European Journal of Medicinal Chemistry. Roč. 44, č. 1 (2009), s. 332-344. ISSN 0223-5234. E-ISSN 1768-3254
Grant CEP: GA ČR GD310/03/H147
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: N-Phenethyl-2-arylacetamides * Antileukotrienic activity * QSAR
Kód oboru RIV: EC - Imunologie
Impakt faktor: 3.269, rok: 2009

We synthetised new arylalkanoic acid derivatives bearing methyl(phenethyl)amino groups. These compounds have ability to inhibit the biosynthesis of pro-inflammatory mediator LTB4. Furthermore, we found that 4 of these compounds are more active in the animal model of ulcerative colitis than sulfasalazine, and could therefore be considered as good candidates for ulcerative colitis therapy
Trvalý link: http://hdl.handle.net/11104/0179858