Počet záznamů: 1

Morphological changes in human neural cells followign tick-borne encephalitis infection

  1. 1.
    0335287 - BC-A 2010 RIV GB eng J - Článek v odborném periodiku
    Růžek, Daniel - Vancová, Marie - Tesařová, Martina - Ahantarig, A. - Kopecký, Jan - Grubhoffer, Libor
    Morphological changes in human neural cells followign tick-borne encephalitis infection.
    Journal of General Virology. Roč. 90, č. 7 (2009), s. 1649-1658 ISSN 0022-1317
    Grant CEP: GA ČR GA524/08/1509; GA MŠk(CZ) LC06009
    Výzkumný záměr: CEZ:AV0Z60220518
    Klíčová slova: tick-borne encephalitis virus * human neural cells * central nervous system
    Kód oboru RIV: EE - Mikrobiologie, virologie
    Impakt faktor: 3.260, rok: 2009

    Tick-borne encephalitis (TBE) is one of the leading and most dangerous human viral neuroinfections in Europe and north-eastern Asia. The clinical manifestations include asymptomatic infections, fevers and debilitating encephalitis that might progress into chronic disease or fatal infection. To understand TBE pathology further in host nervous systems, three human neural cell lines, neuroblastoma, medulloblastoma and glioblastoma, were infected with TBE virus (TBEV). The susceptibility and virus-mediated cytopathic effect, including ultrastructural and apoptotic changes of the cells, were examined. The neuropathological significance of the observations is discussed.
    Trvalý link: http://hdl.handle.net/11104/0179794