Počet záznamů: 1

Proteomic profiling of human embryonic stem cell-derived microvesicles reveals a risk of transfer of proteins of bovine and mouse origin

  1. 1.
    0335110 - UIACH-O 2010 RIV GB eng J - Článek v odborném periodiku
    Kubíková, I. - Konečná, H. - Šedo, O. - Zdráhal, Z. - Řehulka, Pavel - Hříbková, H. - Řehulková, Helena - Hampl, Aleš - Chmelík, Josef - Dvořák, Petr
    Proteomic profiling of human embryonic stem cell-derived microvesicles reveals a risk of transfer of proteins of bovine and mouse origin.
    Cytotherapy. Roč. 11, č. 3 (2009), s. 330-340 ISSN 1465-3249
    Grant CEP: GA MŠk 1M0538
    Výzkumný záměr: CEZ:AV0Z40310501; CEZ:AV0Z50390512; CEZ:AV0Z50390703
    Klíčová slova: human embryonic stem cell * hESC * proteomic profiling
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 2.204, rok: 2009

    Microvesicles (MVs) shed from the plasma membrane of eukaryotic cells including human embryonic stem cells (hESCs) contain proteins, lipids, and RNAs and serve as mediators of cell-to-cell communication. However, they may also contain immunogenic membrane domains or infectious particles acquired from xenogenic components of the culture milieu. Therefore, MVs represent a potential risk for the clinical application of cell therapy.
    Trvalý link: http://hdl.handle.net/11104/0179676