Počet záznamů: 1

DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism

  1. 1.
    0334067 - UMG-J 2010 RIV US eng J - Článek v odborném periodiku
    Zíková, Martina - Corlett, Alicia - Bendová, Zdeňka - Pajer, Petr - Bartůněk, Petr
    DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism.
    Molecular Endocrinology. Roč. 23, č. 4 (2009), s. 520-528 ISSN 0888-8809
    Grant CEP: GA AV ČR IAA500520705
    Grant ostatní: EC(XE) LSHM-CT-2005-018652
    Výzkumný záměr: CEZ:AV0Z50520514; CEZ:AV0Z50110509
    Klíčová slova: thyroid hormone receptor * cholesterol metabolism * sterol-sensing domain
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 5.257, rok: 2009

    In the body the brain is the most cholesterol-rich organ. Despite this, remarkably little is known about the mechanisms in the brain that regulate cholesterol homeostasis. Thyroid hormone receptors, activated in response to thyroid hormone (T3), are known to modulate the level of serum cholesterol via complex regulatory pathways. By screening for T3-regulated genes we identified Disp3, a sterol-sensing protein that is related to the Dispatched family of proteins. Using the model of hyperthyroidism in vivo we observed modulation of the Disp3 expression. DISP3 localizes within the endoplasmic reticulum and was further found to co-localize with cholesterol. Ectopic expression of DISP3 resulted in elevated cholesterol levels combined with an altered cholesterol distribution. Taken together, we propose that DISP3 represents a new molecular link between thyroid hormone and cholesterol metabolism in the brain.
    Trvalý link: http://hdl.handle.net/11104/0178901