Počet záznamů: 1

Eye-specific expression of an ancestral jellyfish PaxB gene interferes with Pax6 function despite its conserved Pax6/Pax2 characteristics

  1. 1.
    0333811 - UMG-J 2010 RIV ES eng J - Článek v odborném periodiku
    Růžičková, Jana - Piatigorsky, J. - Kozmik, Zbyněk
    Eye-specific expression of an ancestral jellyfish PaxB gene interferes with Pax6 function despite its conserved Pax6/Pax2 characteristics.
    International Journal of Developmental Biology. Roč. 53, č. 4 (2009), s. 469-482 ISSN 0214-6282
    Grant CEP: GA AV ČR IAA500520908; GA MŠk(CZ) 1M0520; GA ČR GA204/08/1618
    Výzkumný záměr: CEZ:AV0Z50520514
    Klíčová slova: Eye * Pax * lens
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 2.161, rok: 2009

    Pax transcription factors are evolutionarily conserved regulators of eye development and can be distinguished on the basis of three functional domains: two DNA-binding domains (the paired domain and the paired-type homeodomain), and the octapeptide motif. PaxB of the eyed cubozoan jellyfish, Tripedalia cystophora, is characterized by a Pax2-like paired domain and octapeptide, and a Pax6-like homeodomain. In mice, functionally distinct Pax6 and Pax2 proteins have unique as well as redundant roles in eye morphogenesis. Here, we show that expression of the jellyfish PaxB gene in mouse embryonic eye tissues impairs normal development of lens and retina.
    Trvalý link: http://hdl.handle.net/11104/0178715