Počet záznamů: 1

Anorexigenic effect of cholecystokinin is lost but that of CART (cocaine and amphetamine regulated transcript) peptide is preserved in monosodium glutamate obese mice

  1. 1.
    0333492 - UOCHB-X 2010 RIV CZ eng J - Článek v odborném periodiku
    Železná, Blanka - Maixnerová, Jana - Matyšková, Resha - Haugvicová, Renata - Blokešová, Darja - Maletínská, Lenka
    Anorexigenic effect of cholecystokinin is lost but that of CART (cocaine and amphetamine regulated transcript) peptide is preserved in monosodium glutamate obese mice.
    Physiological Research. Roč. 58, č. 5 (2009), s. 717-723 ISSN 0862-8408
    Grant CEP: GA ČR GA303/05/0614
    Grant ostatní: GA ČR(CZ) GA305/06/0427
    Výzkumný záměr: CEZ:AV0Z40550506; CEZ:AV0Z5020903
    Klíčová slova: monosodium glutamate (MSG) obesity * neuropeptide Y (NPY) * cholecystokinin
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 1.430, rok: 2009

    Monosodium glutamate (MSG) treatment of neonatal mice results in a selective damage to the arcuate nucleus (ARC) and development of obesity. The MSG obese mice do not respond to fasting by an increased food intake which makes difficult to measure the effect of peptides attenuating food intake such as cholecystokinin (CCK) or cocaine- and amphetamine-regulated transcript (CART) peptide. However, orexigenic effect of NPY is preserved in the fed MSG obese rodents. In this study with fed lean and MSG obese C57BL/6 male mice, short-term food intake was measured after simultaneous central administration of orexigenic NPY with either CART peptide or peripherally administered CCK. Anorexigenic action of exogenous CART peptide was preserved in MSG obese mice. On the other hand, satiety effect of exogenous CCK was completely lost in MSG obese mice probably because of ineffective leptin signaling in ARC.
    Trvalý link: http://hdl.handle.net/11104/0178458