Počet záznamů: 1

Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III

  1. 1.
    0333023 - UOCHB-X 2010 RIV GB eng J - Článek v odborném periodiku
    Hlouchová, Klára - Bařinka, C. - Konvalinka, Jan - Lubkowski, J.
    Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III.
    FEBS Journal. Roč. 276, č. 16 (2009), s. 4448-4462 ISSN 1742-464X
    Grant CEP: GA MŠk 1M0508
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: GCPIII * NAALADase II * metallopeptidase
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 3.042, rok: 2009

    The study reports of several functional complexes of recombinant human GCPIII that allow for a direct comparison with equivalent GCPII complexes. That reveals differences in the organization of specificity pockets, in surface charge distribution, and in the occupancy of the co-catalytic zinc sites. The data presented here provide information that should prove to be essential for the structurally- aided design of GCPIII-specific ligands.
    Trvalý link: http://hdl.handle.net/11104/0178112