Počet záznamů: 1

Mechanism of formation of (deoxy)guanosine adducts derived from peroxidase-catalyzed oxidation of the carcinogenic nonaminoazo dye 1-phenylazo-2-hydroxynaphthalene (Sudan I)

  1. 1.
    0332891 - UOCHB-X 2010 RIV US eng J - Článek v odborném periodiku
    Dračínský, Martin - Cvačka, Josef - Semanská, M. - Martínek, V. - Frei, E. - Stiborová, M.
    Mechanism of formation of (deoxy)guanosine adducts derived from peroxidase-catalyzed oxidation of the carcinogenic nonaminoazo dye 1-phenylazo-2-hydroxynaphthalene (Sudan I).
    Chemical Research in Toxicology. Roč. 22, č. 11 (2009), s. 1765-1773 ISSN 0893-228X
    Grant CEP: GA AV ČR KJB400550903
    Grant ostatní:GA ČR(CZ) GA303/09/0472; GA ČR(CZ) GA203/09/0812
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: Sudan I * peroxidase * NMR spectroscopy * (deoxy)guanosin adducts
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 3.740, rok: 2009

    We investigated peroxidase-mediated oxidation of and (deoxy)guanosine adduct formation by 1-phenylazo-2-hydroxynaphthalene (Sudan I), a liver and urinary bladder carcinogen for rodents. Using TLC and/or HPLC combined with mass and/or NMR spectrometry, we characterized the structures of two major peroxidase-mediated Sudan I metabolites and those of adducts of (deoxy)guanosine that are formed during Sudan I oxidation.
    Trvalý link: http://hdl.handle.net/11104/0178011