Human fetal colon cells and colon cancer cells respond differently to butyrate and PUFAs

0332328 - BFÚ 2010 RIV DE eng J - Článek v odborném periodiku
Hofmanová, Jiřina - Vaculová, Alena - Koubková, Zuzana - Hýžďalová, Martina - Kozubík, Alois
Human fetal colon cells and colon cancer cells respond differently to butyrate and PUFAs.
Molecular Nutrition & Food Research. Roč. 53, č. 1 (2009), S102-S113. ISSN 1613-4125. E-ISSN 1613-4133
Grant CEP: GA ČR(CZ) GA524/07/1178; GA AV ČR(CZ) 1QS500040507; GA ČR(CZ) GA301/07/1557
Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Klíčová slova: apoptosis * butyrate * cell differentiation
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 4.356, rok: 2009

Comparing human colon epithelial cell lines of fetal (FHC) and adenocarcinoma (HT-29, HCT-116) origin, we detected significant differences in proliferation, differentiation, and apoptotic response to the treatment of sodium butyrate (NaBt), arachidonic or docosahexaenoic acids, and their combination. Our results support the concept of modulation of NaBt effects by polyunsaturated fatty acids, especially of omega-3 type, in colonic cells in vitro with diverse impact in cell lines derived from normal or neoplastic epithelium.
Trvalý link: http://hdl.handle.net/11104/0177620