Počet záznamů: 1

Human fetal colon cells and colon cancer cells respond differently to butyrate and PUFAs

  1. 1.
    0332328 - BFU-R 2010 RIV DE eng J - Článek v odborném periodiku
    Hofmanová, Jiřina - Vaculová, Alena - Koubková, Zuzana - Hýžďalová, Martina - Kozubík, Alois
    Human fetal colon cells and colon cancer cells respond differently to butyrate and PUFAs.
    Molecular Nutrition & Food Research. Roč. 53, č. 1 (2009), S102-S113 ISSN 1613-4125
    Grant CEP: GA ČR(CZ) GA524/07/1178; GA AV ČR(CZ) 1QS500040507; GA ČR(CZ) GA301/07/1557
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: apoptosis * butyrate * cell differentiation
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 4.356, rok: 2009

    Comparing human colon epithelial cell lines of fetal (FHC) and adenocarcinoma (HT-29, HCT-116) origin, we detected significant differences in proliferation, differentiation, and apoptotic response to the treatment of sodium butyrate (NaBt), arachidonic or docosahexaenoic acids, and their combination. Our results support the concept of modulation of NaBt effects by polyunsaturated fatty acids, especially of omega-3 type, in colonic cells in vitro with diverse impact in cell lines derived from normal or neoplastic epithelium.
    Trvalý link: http://hdl.handle.net/11104/0177620