Počet záznamů: 1

Replication of Restless Legs Syndrome Loci in Three European Populations

  1. 1.
    0331384 - UEM-P 2010 RIV GB eng J - Článek v odborném periodiku
    Kemlink, D. - Polo, O. - Frauscher, B. - Gschliesser, V. - Högl, B. - Poewe, W. - Vodička, Pavel - Vávrová, J. - Šonka, K. - Nevšímalová, S. - Schormair, B. - Lichtner, P. - Silander, K. - Peltonen, L. - Gieger, C. - Wichmann, H. E. - Zimprich, A. - Roeske, D. - Müller-Myhsok, B. - Meitinger, T. - Winkelmann, J.
    Replication of Restless Legs Syndrome Loci in Three European Populations.
    Journal of Medical Genetics. Roč. 46, č. 5 (2009), s. 315-318 ISSN 0022-2593
    Grant CEP: GA MZd NR8563
    Grant ostatní:GA MŠk(CZ) MSM0021620816
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: periodic limb movements * genetic risk-factor * susceptibility locus
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 5.751, rok: 2009

    Restless legs syndrome (RLS) is associated with common variants in three intronic and intergenic regions in MEIS1, BTBD9, and MAP2K5/LBXCOR1 on chromosomes 2p, 6p and 15q. Our study shows that variants in these three loci confer consistent disease risks in patients of European descent. Among the known loci, BTBD9 seems to be the most consistent in its effect on RLS across populations and is also most independent of familial clustering.
    Trvalý link: http://hdl.handle.net/11104/0176913