Počet záznamů: 1

Enhanced expressions of mRNA for neuropeptide Y and interleukin 1 beta in hypothalamic arcuate nuclei during adjuvant arthritis-induced anorexia in Lewis rats

  1. 1.
    0330845 - UOCHB-X 2010 RIV CH eng J - Článek v odborném periodiku
    Stofková, A. - Haluzík, M. - Železná, Blanka - Kiss, A. - Skurlová, M. - Lacinová, Z. - Jurcovicová, J.
    Enhanced expressions of mRNA for neuropeptide Y and interleukin 1 beta in hypothalamic arcuate nuclei during adjuvant arthritis-induced anorexia in Lewis rats.
    Neuroimmunomodulation. Roč. 16, č. 6 (2009), s. 377-384 ISSN 1021-7401
    Grant CEP: GA ČR GA305/06/0427
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: adjuvant arthritis * anorexia * leptin * adiponectin
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 2.034, rok: 2009

    Food intake is activated by hypothalamic orexigenic neuropeptide Y (NPY) controlled by leptin and ghrelin. Rat adjuvant arthritis (AA), and also human rheumatoid arthritis, is associated with cachexia. In our study, we evaluated NPY expression in hypothalamic arcuate nucleus (nARC) under AA-induced changes in leptin, ghrelin and adiponectin. Anorexia is centrally induced by IL-1β whose expression in the nARC was studied as well. In AA rats, decreased appetite, body mass, and epididymal fat positively correlated with reduced circulating and epididymal fat leptin and adiponectin. Plasma ghrelin was increased. In nARC, mRNA for leptin and ghrelin receptors, NPY, and IL-1beta were over-expressed in AA rats. However, circulating and spleen IL-1beta was unaltered in AA rats. During AA, despite of over-expression of orexigenic NPY in nARC, activated expression of IL-1beta in nARC kept AA-induced anorexia in progress. Lowered adiponectin might contribute to this anorexia.
    Trvalý link: http://hdl.handle.net/11104/0176533