Počet záznamů: 1

The impact of air pollution on the level of micronuclei measured by automated image analysis

  1. 1.
    0330452 - UEM-P 2010 RIV NL eng J - Článek v odborném periodiku
    Rössnerová, Andrea - Špátová, Milada - Rossner, P. - Solanský, I. - Šrám, Radim
    The impact of air pollution on the level of micronuclei measured by automated image analysis.
    Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. Roč. 669, 1-2 (2009), s. 42-47 ISSN 0027-5107
    Grant CEP: GA AV ČR 1QS500390506; GA MŠk 2B06088; GA MŠk 2B08005
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: micronuclei * binucleated cells * automated image analysis
    Kód oboru RIV: DN - Vliv životního prostředí na zdraví
    Impakt faktor: 3.556, rok: 2009

    The results of a human biomonitoring study focused on the measurement of micronuclei (MN) by automated image analysis (MetaSystems Metafer 4) for assessing chromosomal damage as a result of environmental mutagen exposure. In a group of 56 city policemen from Prague the effect of exposure to carcinogenic polycyclic aromatic hydrocarbons (c-PAHs), volatile organic compounds and smoking on the frequency of MN was evaluated. The results demonstrate the ability of c-PAHs to increase MN frequency and confirm no differences between smokers and nonsmokers. It was confirmed that automatic image analysis of MN is a highly sensitive method for evaluating chromosomal damage by environmental pollution.
    Trvalý link: http://hdl.handle.net/11104/0176239