Počet záznamů: 1

Dynamics of Trace Element Concentration During Development and Excitotoxic Cell Death in the Cerebellum of Lurcher Mutant Mice

  1. 1.
    0330364 - UJF-V 2010 RIV US eng J - Článek v odborném periodiku
    Bäurle, J. - Kučera, Jan - Frischmuth, S. - Lambertz, M. - Kranda, Karel
    Dynamics of Trace Element Concentration During Development and Excitotoxic Cell Death in the Cerebellum of Lurcher Mutant Mice.
    Brain Pathology. Roč. 19, č. 4 (2009), s. 586-595 ISSN 1015-6305
    Grant CEP: GA ČR GA309/09/1189
    Výzkumný záměr: CEZ:AV0Z10480505
    Klíčová slova: apoptosis * copper * excitotoxicity
    Kód oboru RIV: BG - Jaderná, atomová a mol. fyzika, urychlovače
    Impakt faktor: 5.903, rok: 2009

    Elevated concentrations of Zn, Cu and Fe, observed in biopsied or post-mortem tissue from diseased human brains, have often been considered as some of the major factors in the etiology of excitotoxic neuronal death but without any direct evidence for the causal role of metals. Although elevated metal concentrations that precede or coincide with the onset of neurodegeneration may provide such evidence, the dynamics of metal concentrations during excitotoxic cell death has never been established. Hence, we measured time-resolved Zn, Cu and Fe concentrations during the course of excitotoxic cell death in the Lurcher (Lc/+) mutant mouse with neutron activation analysis.
    Trvalý link: http://hdl.handle.net/11104/0176171