Počet záznamů: 1

Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase

  1. 1.
    0329066 - UOCHB-X 2010 RIV GB eng J - Článek v odborném periodiku
    Hocková, Dana - Holý, Antonín - Masojídková, Milena - Keough, D. T. - de Jersey, J. - Guddat, L. W.
    Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.
    Bioorganic & Medicinal Chemistry. Roč. 17, č. 17 (2009), s. 6218-6232 ISSN 0968-0896
    Grant CEP: GA MŠk 1M0508; GA AV ČR 1QS400550501
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: acyclic nucleoside phosphonates * drug design * phosphoribosyltransferase * enzyme inhibitors * purine salvage pathway
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 2.822, rok: 2009

    Hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT) is the key enzyme in purine metabolism of the malarial parasite Plasmodium falciparum (Pf). Two series of novel branched ANPs derived from 9-[2-(2-phosphonoethoxy)ethyl]purines were synthesized to investigate their inhibition of Pf and human 6-oxopurine phosphoribosyltransferase.
    Trvalý link: http://hdl.handle.net/11104/0175201