Počet záznamů: 1

Tetrathiafulvalene-labelled nucleosides and nucleoside triphosphates. Synthesis, electrochemistry and scope of their polymerase incorporation into DNA

  1. 1.
    0328740 - UOCHB-X 2010 RIV DE eng J - Článek v odborném periodiku
    Riedl, Jan - Horáková Brázdilová, Petra - Šebest, Peter - Pohl, Radek - Havran, Luděk - Fojta, Miroslav - Hocek, Michal
    Tetrathiafulvalene-labelled nucleosides and nucleoside triphosphates. Synthesis, electrochemistry and scope of their polymerase incorporation into DNA.
    European Journal of Organic Chemistry. -, č. 21 (2009), s. 3519-3525 ISSN 1434-193X
    Grant CEP: GA AV ČR(CZ) IAA400040901
    Výzkumný záměr: CEZ:AV0Z40550506; CEZ:AV0Z50040507
    Klíčová slova: nucleoside triphosphates * DNA polymerase * tetrathiafulvalene
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 3.096, rok: 2009

    DNA labeling by tetrathiafulvalene was attempted. TTF-modified nucleoside triphosphates were prepared and tested as substrates for DNA polymerases. Their enzymatic incorporation was inefficient and at higher concentration they fully inhibited the polymerase.
    Trvalý link: http://hdl.handle.net/11104/0174977