Počet záznamů: 1

Cbf11 and Cbf12, the fission yeast CSL proteins, play opposing roles in cell adhesion and coordination of cell and nuclear division

  1. 1.
    0328355 - MBU-M 2010 RIV US eng J - Článek v odborném periodiku
    Převorovský, M. - Groušl, Tomáš - Staňurová, J. - Ryneš, J. - Nellen, W. - Půta, F. - Folk, P.
    Cbf11 and Cbf12, the fission yeast CSL proteins, play opposing roles in cell adhesion and coordination of cell and nuclear division.
    Experimental Cell Research. Roč. 315, č. 8 (2009), s. 1533-1547 ISSN 0014-4827
    Grant CEP: GA ČR(CZ) GD204/03/H066
    Grant ostatní: UK(CZ) 157/2005/B-BIO/PrF
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: csl family * fission yeast * adhesion
    Kód oboru RIV: EE - Mikrobiologie, virologie
    Impakt faktor: 3.589, rok: 2009

    The CSL (CBF1/RBP-J/Suppressor of Hairless/LAG-1) family is comprised of transcription factors essential for metazoan development, mostly due to their involvement in the Notch receptor signaling pathway. Recently, we identified two novel classes of CSL genes in the genomes of several fungal species, organisms lacking the Notch pathway. In this study, we characterized experimentally cbf11plus and cbf12plus, the two CSL genes of Schizosaccharomyces pombe, in order to elucidate the CSL function in fungi. We provide evidence supporting their identity as genuine CSL genes. Both cbf11plus and cbf12plus are non-essential, they have distinct expression profiles and code for nuclear proteins with transcription activation potential. Significantly, we demonstrated that Cbf11 recognizes specifically the canonical CSL response element GTGA/GGAA in vitro
    Trvalý link: http://hdl.handle.net/11104/0174687