Počet záznamů: 1

Stimuli-responsive nanoparticles based on interaction of metallacarborane with poly(ethylene oxide)

  1. 1.
    0327533 - UMCH-V 2010 RIV US eng J - Článek v odborném periodiku
    Matějíček, P. - Zedník, J. - Ušelová, K. - Pleštil, Josef - Fanfrlík, Jindřich - Nykanen, A. - Ruokolainen, J. - Hobza, Pavel - Procházka, K.
    Stimuli-responsive nanoparticles based on interaction of metallacarborane with poly(ethylene oxide).
    Macromolecules. Roč. 42, č. 13 (2009), s. 4829-4837 ISSN 0024-9297
    Grant CEP: GA ČR(CZ) GD203/05/H001; GA AV ČR 1ET400500402; GA AV ČR IAAX00320901
    Výzkumný záměr: CEZ:AV0Z40500505; CEZ:AV0Z40550506
    Klíčová slova: block-copolymer micelles * light-scattering * dicarbollide anions
    Kód oboru RIV: CD - Makromolekulární chemie
    Impakt faktor: 4.539, rok: 2009

    The antiviral active boron cluster [3-cobalt bis(1,2-dicarbollide)](-1) anion, CoD, interacts and forms a stable complex with one of the most widely used polymeric component of drug delivery systems: poly(ethylene oxide), PEO. The formation of insoluble NaCoD/PEO complex can be exploited in design of water-soluble metallacarborane-containing nanoparticles that could offer applications in medicine. We studied the boron cluster interaction with a hydrophilic block copolymer: poly(ethylene oxide)-block-poly(methacrylic acid), PEO-PMA. The interaction leads to a spontaneous formation of core-shell nanoparticles. The insoluble core contains the PEO/CoD complex, while the polyanionic PMA blocks, which do not interact with the metallacarborane, form the pH-responsive micellar shell and stabilize the particles in aqueous media.
    Trvalý link: http://hdl.handle.net/11104/0005384