Počet záznamů: 1

- Hydroxylated Anthraquinones Produced by Geosmithia species

  1. 1.
    0327075 - MBU-M 2010 RIV CZ eng J - Článek v odborném periodiku
    Stodůlková, Eva - Kolařík, Miroslav - Křesinová, Zdena - Kuzma, Marek - Šulc, Miroslav - Man, Petr - Novák, Petr - Maršík, Petr - Landa, Přemysl - Olšovská, Jana - Chudíčková, Milada - Pažoutová, Sylvie - Černý, J. - Bella, J. - Flieger, Miroslav
    - Hydroxylated Anthraquinones Produced by Geosmithia species.
    Folia Microbiologica. Roč. 54, č. 3 (2009), s. 179-187 ISSN 0015-5632
    Grant CEP: GA AV ČR KAN200200651; GA MŠk LC07017; GA MŠk 1M0506; GA ČR GP203/05/P575
    Grant ostatní:CZ(CZ) 205/2004
    Výzkumný záměr: CEZ:AV0Z50200510; CEZ:AV0Z50380511
    Klíčová slova: hydroxylated anthraquinones * staphylococcus aureus * mammalian cell lines
    Kód oboru RIV: EE - Mikrobiologie, virologie
    Impakt faktor: 0.978, rok: 2009

    Hydroxylated anthraquinones (yellow, orange, and red pigments), were found to be the most abundant compounds produced into the medium during the submerged cultivation. Three main compounds were identified as 1,3,6,8-tetrahydroxyanthraquinone (1), rhodolamprometrin (1-acetyl-2,4,5,7-tetrahydroxyanthraquinone; 2), and 1-acetyl-2,4,5,7,8-pentahydroxyanthraquinone (3). Compounds 2 and 3 (representing the majority of produced metabolites) inhibited the growth of G plus minus bacteria Staphylococcus aureus and Bacillus subtilis with minimum inhibitory concentration of 64–512 g/mL. Anti-inflammatory activity detected as inhibition of cyclooxygenase-2 was found only for compound 3 at 1 and 10 g/mL. Compound 2 interfered with the morphology, compound 3 with cell-cycle dynamics of adherent mammalian cell lines
    Trvalý link: http://hdl.handle.net/11104/0173976