Počet záznamů: 1

IrAM—An .alpha..sub.2./sub.-macroglobulin from the hard tick Ixodes ricinus: Characterization and function in phagocytosis of a potential pathogen Chryseobacterium indologenes

  1. 1.
    0327045 - BC-A 2010 RIV GB eng J - Článek v odborném periodiku
    Burešová, Veronika - Hajdušek, Ondřej - Franta, Zdeněk - Sojka, Daniel - Kopáček, Petr
    IrAM—An .alpha.2-macroglobulin from the hard tick Ixodes ricinus: Characterization and function in phagocytosis of a potential pathogen Chryseobacterium indologenes.
    Developmental and Comparative Immunology. Roč. 33, č. 4 (2009), s. 489-198 ISSN 0145-305X
    Grant CEP: GA AV ČR IAA600220603; GA MŠk(CZ) LC06009
    Výzkumný záměr: CEZ:AV0Z60220518
    Klíčová slova: α2-macroglobulin * tick * phagocytosis
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 3.290, rok: 2009

    We have cloned, sequenced and characterized an macromolecular protease inhibitor of α2-macroglobulin family from the hard tick Ixodes ricinus named IrAM. Using the tool of RNA interference we have demonstrated that IrAM is an important constituent of tick innate immunity since it is involved in the phagocytosis of the pathogen Chryseobacterium indologenes by tick hemocytes. This is the first evidence showing that a cellular immune response in invertebrates is linked with interaction of an plasma α2-macroglobulin with protease derived from invading pathogen.
    Trvalý link: http://hdl.handle.net/11104/0173950