Počet záznamů: 1

Robust heat shock induces eIF2α-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae

  1. 1.
    0326270 - MBU-M 2009 RIV GB eng J - Článek v odborném periodiku
    Groušl, Tomáš - Ivanov, P. - Frýdlová, Ivana - Vašicová, Pavla - Janda, Filip - Vojtová, Jana - Malínská, Kateřina - Malcová-Janatová, Ivana - Nováková, Lenka - Janošková, Dana - Valášek, Leoš - Hašek, Jiří
    Robust heat shock induces eIF2α-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae.
    Journal of Cell Science. Roč. 122, č. 12 (2009), s. 2078-2088 ISSN 0021-9533
    Grant CEP: GA ČR GA204/02/1424; GA ČR GA204/05/0838; GA ČR GA204/09/1924; GA MŠk LC545; GA MŠk ME 939
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: p-bodies * stress granules * yeast
    Kód oboru RIV: EE - Mikrobiologie, virologie
    Impakt faktor: 6.144, rok: 2009

    Formation of stres granules (SGs) has not yet been described in S. cerevisiae. We showed that robust heat shock induced accumulation of eIF3a/Tif32p/Rpg1p in cytoplasmic foci. They also contained eIF3b/Prt1p, eIF3c/Nip1p, eIF4G2, Pab1p, mRNA and small but not large ribosomes and eIF2a/Sui2p. Surprisingly, Dcp2p and Dhh1p P-body markers also co-localized with eIF3a, however, since formation of eIF3-accumulations required different scaffolding proteins than P-bodies, we suggest that they represent yeast specific SGs
    Trvalý link: http://hdl.handle.net/11104/0173421