Počet záznamů: 1

Astroglia in dementia and Alzheimer´s disease

  1. 1.
    0317550 - UEM-P 2010 RIV GB eng J - Článek v odborném periodiku
    Rodríguez Arellano, Jose Julio - Olabarria, M. - Chvátal, Alexandr - Verkhratsky, Alexei
    Astroglia in dementia and Alzheimer´s disease.
    Cell Death and Differentiation. Roč. 16, č. 3 (2009), s. 378-385 ISSN 1350-9047
    Grant CEP: GA ČR GA305/06/1316; GA ČR GA305/06/1464; GA ČR GA309/08/1381; GA MŠk(CZ) LC554; GA ČR GA305/08/1384
    Grant ostatní: GA MŠk(CZ) 1M0538
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: astrocyte * alia-Alzheimer´s disease * dementia
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 8.240, rok: 2009

    Astrocytes, the most numerous cells in the brain, weave the canvas of the grey matter and act as the main element of the homoeostatic system of the brain. We show that in the transgenic model of Alzheimer's disease, reactive hypertrophic astrocytes surround the neuritic plaques, whereas throughout the brain parenchyma astroglial cells undergo atrophy. Astroglial atrophy may account for early changes in synaptic plasticity and cognitive impairments, which develop before gross neurodegenerative alterations.
    Trvalý link: http://hdl.handle.net/11104/0167164