Počet záznamů: 1  

Comparison of intraspinal and intrathecal implantation of induced pluripotent stem cell-derived neural precursors for the treatment of spinal cord injury in rats

  1. 1. 0454661 - UEM-P 2016 RIV GB eng J - Článek v odborném periodiku
    Amemori, Takashi - Růžička, Jiří - Romanyuk, Nataliya - Jhanwar-Uniyal, M. - Syková, Eva - Jendelová, Pavla
    Comparison of intraspinal and intrathecal implantation of induced pluripotent stem cell-derived neural precursors for the treatment of spinal cord injury in rats.
    Stem Cell Research & Therapy. Roč. 6, Dec (2015), s. 257 ISSN 1757-6512
    Grant CEP: GA MŠk(CZ) LH12024
    Institucionální podpora: RVO:68378041
    Klíčová slova: spinal cord injury * human induced pluripotent stem cells * cell therapy * cell application route
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 4.504, rok: 2015

    In the present study, we administered neural precursors derived from induced pluripotent stem cells (iPS-NPs) either intraspinally into the lesion center or intrathecally into the subarachnoid space of rats with a balloon-induced spinal cord compression lesion. Both treatments facilitated the functional locomotor recovery of rats with SCI. Intrathecal application of iPS-NPs has a positive therapeutic influence (resulting in locomotor improvement, moderate tissue sparing and axonal sprouting) on SCI through a paracrine mechanism that does not require the presence of cells in the tissue. However, the extended survival of intraspinally grafted cells in the spinal cord may promote long-term spinal cord tissue regeneration.
    Trvalý link: http://hdl.handle.net/11104/0255376