Search results
- 1.0575132 - ÚOCHB 2024 RIV US eng J - Journal Article
Solntseva, E. I. - Bukanova, J. V. - Kondratenko, R. - Kudová, Eva
Corticosteroids as Selective and Effective Modulators of Glycine Receptors.
ACS Chemical Neuroscience. Roč. 14, č. 17 (2023), s. 3132-3142. ISSN 1948-7193. E-ISSN 1948-7193
R&D Projects: GA MŠMT(CZ) LX22NPO5104
Institutional support: RVO:61388963
Keywords : GABAA receptor * glycine receptor * corticosteroids * structure-activity relationship study
OECD category: Neurosciences (including psychophysiology
Impact factor: 5, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acschemneuro.3c00287
Permanent Link: https://hdl.handle.net/11104/0344992File Download Size Commentary Version Access 10.1021acschemneuro.3c00287.pdf 0 4 MB Publisher’s postprint open-access - 2.0558551 - ÚOCHB 2023 RIV US eng J - Journal Article
Solntseva, E. I. - Bukanova, J. V. - Skrebitsky, V. G. - Kudová, Eva
Pregnane neurosteroids exert opposite effects on GABA and glycine-induced chloride current in isolated rat neurons.
Hippocampus. Roč. 32, č. 7 (2022), s. 552-563. ISSN 1050-9631. E-ISSN 1098-1063
R&D Projects: GA MZd(CZ) EF16_025/0007444
Institutional support: RVO:61388963
Keywords : GABA(A) receptor * glycine receptor * neurosteroid * pregnane * structure-activity relationship study
OECD category: Neurosciences (including psychophysiology
Impact factor: 3.5, year: 2022
Method of publishing: Limited access
https://doi.org/10.1002/hipo.23449
Permanent Link: http://hdl.handle.net/11104/0332190 - 3.0543824 - ÚMG 2022 RIV GB eng J - Journal Article
Oleksak, P. - Psotka, M. - Vančurová, Markéta - Sapega, Olena - Bieblová, Jana - Reiniš, Milan - Ryšánek, David - Mikyšková, Romana - Chalupová, K. - Malinak, D. - Svobodová, J. - Andrýs, R. - Řehulková, H. - Skopek, V. - Ngoc Lam, P. - Bártek, Jiří - Hodný, Zdeněk - Musílek, K.
Design, synthesis, and in vitro evaluation of BP-1-102 analogs with modified hydrophobic fragments for STAT3 inhibition.
Journal of Enzyme Inhibition and Medicinal Chemistry. Roč. 36, č. 1 (2021), s. 410-424. ISSN 1475-6366. E-ISSN 1475-6374
R&D Projects: GA ČR(CZ) GA18-14259S
Institutional support: RVO:68378050
Keywords : STAT3 signalling pathway * cancer * SH2 domain * inhibitor * structure-activity relationship
OECD category: Biochemistry and molecular biology
Impact factor: 5.756, year: 2021
Method of publishing: Open access
https://www.tandfonline.com/doi/full/10.1080/14756366.2020.1871336
Permanent Link: http://hdl.handle.net/11104/0320942 - 4.0539170 - ÚMG 2021 RIV GB eng J - Journal Article
Kugler, Michael - Holub, J. - Brynda, Jiří - Pospíšilová, K. - El Anwar, S. - Bavol, D. - Havránek, M. - Král, Vlastimil - Fábry, Milan - Gruner, B. - Řezáčová, Pavlína
The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX.
Journal of Enzyme Inhibition and Medicinal Chemistry. Roč. 35, č. 1 (2020), s. 1800-1810. ISSN 1475-6366. E-ISSN 1475-6374
Institutional support: RVO:68378050
Keywords : tumor hypoxia * medicinal chemistry * drug discovery * binding-sites * inhibition * boron * pharmacophores * opportunities * conjugation * metastasis * Carbonic anhydrase IX * carborane * enzyme inhibitors * structure-activity relationship
OECD category: Biochemistry and molecular biology
Impact factor: 5.051, year: 2020
Method of publishing: Open access
https://www.tandfonline.com/doi/full/10.1080/14756366.2020.1816996
Permanent Link: http://hdl.handle.net/11104/0316870 - 5.0532715 - ÚOCHB 2021 RIV GB eng J - Journal Article
Kugler, Michael - Holub, Josef - Brynda, Jiří - Pospíšilová, Klára - El Anwar, Suzan - Bavol, Dmytro - Havránek, M. - Král, V. - Fábry, M. - Grüner, Bohumír - Řezáčová, Pavlína
The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX.
Journal of Enzyme Inhibition and Medicinal Chemistry. Roč. 35, č. 1 (2020), s. 1800-1810. ISSN 1475-6366. E-ISSN 1475-6374
R&D Projects: GA ČR(CZ) GA18-27648S; GA TA ČR(CZ) TE01020028; GA MŠMT(CZ) EF16_019/0000729
Grant - others:AV ČR(CZ) L200321851
Program: Program podpory perspektivníchlidských zdrojů - postdoktorandů
Institutional support: RVO:61388963 ; RVO:61388980
Keywords : carbonic anhydrase IX * carbone * enzyme inhibitors * sulfonamide * structure-activity relationship
OECD category: Biochemistry and molecular biology; Inorganic and nuclear chemistry (UACH-T)
Impact factor: 5.051, year: 2020
Method of publishing: Open access
https://doi.org/10.1080/14756366.2020.1816996
Permanent Link: http://hdl.handle.net/11104/0311123File Download Size Commentary Version Access The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer associated carbonic anhydrase IX.pdf 2 3.7 MB Publisher’s postprint open-access - 6.0531674 - ÚEB 2021 RIV US eng J - Journal Article
Korda, A. - Rárová, Lucie - Pakulski, Z. - Strnad, Miroslav - Oklešťková, Jana - Kuczynska, K. - Cmoch, P. - Gwardiak, K. - Karczewski, R.
New lupane bidesmosides exhibiting strong cytotoxic activities in vitro.
Bioorganic Chemistry. Roč. 100, JUL (2020), č. článku 103868. ISSN 0045-2068. E-ISSN 1090-2120
R&D Projects: GA ČR(CZ) GA20-25308S
Institutional support: RVO:61389030
Keywords : Betulin bidesmosides * Birch bark * Cytotoxic activity * Structure–activity relationship * Synthesis
OECD category: Medicinal chemistry
Impact factor: 5.275, year: 2020
Method of publishing: Open access
http://doi.org/10.1016/j.bioorg.2020.103868
Permanent Link: http://hdl.handle.net/11104/0310291File Download Size Commentary Version Access 2020_Korda_BIOORGANIC CHEMISTRY_103868.pdf 1 701.4 KB Other open-access - 7.0523573 - ÚOCHB 2021 RIV CH eng J - Journal Article
Bukanova, J. V. - Solntseva, E. I. - Kudová, Eva
Neurosteroids as Selective Inhibitors of Glycine Receptor Activity: Structure-Activity Relationship Study on Endogenous Androstanes and Androstenes.
Frontiers in Molecular Neuroscience. Roč. 13, Mar 20 (2020), č. článku 44. ISSN 1662-5099. E-ISSN 1662-5099
R&D Projects: GA TA ČR(CZ) TN01000013
Institutional support: RVO:61388963
Keywords : neurosteroid * GABA receptor * glycine receptor * androstane * structure-activity relationship
OECD category: Neurosciences (including psychophysiology
Impact factor: 5.639, year: 2020
Method of publishing: Open access
https://www.frontiersin.org/articles/10.3389/fnmol.2020.00044/full
Permanent Link: http://hdl.handle.net/11104/0307915 - 8.0503195 - ÚMG 2019 RIV CZ eng M - Monography Chapter
Škuta, Ctibor
QSAR - Searching for a relationship between a compound’s structure and its biological aktivity. Advances in Chemical Biology.
Advances in Chemical Biology. Praha: OPTIO CZ, 2019 - (Bartůněk, P.), s. 187-196. ISBN 978-80-88011-03-3
R&D Projects: GA MŠMT LO1220
Institutional support: RVO:68378050
Keywords : Quantitative structure-activity relationship modelling * QSAR classification model * small-molecular compound * biological activity
OECD category: Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)
Permanent Link: http://hdl.handle.net/11104/0295020 - 9.0498559 - ÚOCHB 2019 RIV CH eng J - Journal Article
Adla, Santosh Kumar - Slavíková, Barbora - Chodounská, Hana - Vyklický, Vojtěch - Ladislav, Marek - Hubálková, Pavla - Krausová, Barbora - Smejkalová, Tereza - Nekardová, Michaela - Šmídková, Markéta - Monincová, Lenka - Souček, Radko - Vyklický ml., Ladislav - Kudová, Eva
Strong Inhibitory Effect, Low Cytotoxicity and High Plasma Stability of Steroidal Inhibitors of N-Methyl-D-Aspartate Receptors With C-3 Amide Structural Motif.
Frontiers in Pharmacology. Roč. 9, Nov 12 (2018), č. článku 1299. ISSN 1663-9812. E-ISSN 1663-9812
R&D Projects: GA TA ČR(CZ) TE01020028; GA ČR(CZ) GBP208/12/G016; GA ČR(CZ) GA17-02300S; GA ČR(CZ) GJ16-03913Y; GA MZd(CZ) NV15-29370A; GA MŠMT LO1302; GA MŠMT(CZ) ED1.1.00/02.0109
Grant - others:AV ČR(CZ) MSM200111601
Program: Program na podporu mezinárodní spolupráce začínajících výzkumných pracovníků
Institutional support: RVO:61388963 ; RVO:67985823
Keywords : neurosteroid * amide * NMDA receptor * plasma stability * structure-activity relationship
OECD category: Biochemistry and molecular biology
Impact factor: 3.845, year: 2018
https://www.frontiersin.org/articles/10.3389/fphar.2018.01299/full
Permanent Link: http://hdl.handle.net/11104/0291127 - 10.0492171 - ÚOCHB 2019 RIV GB eng J - Journal Article
Bukanova, J. V. - Solntseva, E. I. - Kolbaev, S. N. - Kudová, Eva
Modulation of GABA and glycine receptors in rat pyramidal hippocampal neurones by 3 alpha 5 beta-pregnanolone derivatives.
Neurochemistry International. Roč. 118, Sep (2018), s. 145-151. ISSN 0197-0186. E-ISSN 1872-9754
R&D Projects: GA TA ČR(CZ) TE01020028
Institutional support: RVO:61388963
Keywords : neurosteroid * GABA receptor * glycine receptor * pregnanolone * structure-activity relationship
OECD category: Biochemistry and molecular biology
Impact factor: 3.994, year: 2018
Permanent Link: http://hdl.handle.net/11104/0285725