Search results
- 1.0576067 - ÚEB 2024 RIV cze P - Patent Document
Cankař, Petr - Tomanová, Monika - Jedinák, L. - Kryštof, Vladimír - Jorda, Radek - Řezníčková, Eva - Strnad, Miroslav
Substituované purinové sloučeniny jako inhibitory proteinkináz, jejich použití jako léčiva a farmaceutické přípravky obsahující tyto deriváty.
[Substituted purine compounds as protein kinase inhibitors, their use as medicaments and pharmaceutical preparations containing these derivatives.]
2022. Owner: Ústav experimentální botaniky AV ČR, v. v. i. Date of the patent acceptance: 17.08.2022. Patent Number: 309356. Territorial Protection: národní patent v členském státě EU .
Institutional support: RVO:61389030
Keywords : purines * purine alkylation * acyclic nucleosides
OECD category: Organic chemistry
https://isdv.upv.cz/doc/FullFiles/Patents/FullDocuments/309/309356.pdf
Permanent Link: https://hdl.handle.net/11104/0345691File Download Size Commentary Version Access 2022_Cankar_patent_CZ309356.pdf 2 1.1 MB Other open-access - 2.0541528 - ÚMG 2021 RIV US eng J - Journal Article
Jorda, R. - Havlíček, L. - Šturc, A. - Tušková, D. - Daumová, L. - Alam, M. - Škerlová, Jana - Nekardová, M. - Peřina, M. - Pospíšil, T. - Šiiroká, J. - Urbánek, L. - Pachl, P. - Řezáčová, Pavlína - Strnad, M. - Klener, P. - Kryštof, V.
3,5,7-Substituted Pyrazolo[4,3-d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models.
Journal of Medicinal Chemistry. Roč. 62, č. 9 (2019), s. 4606-4623. ISSN 0022-2623. E-ISSN 1520-4804
Institutional support: RVO:68378050
Keywords : biological evaluation * cell-cycle * roscovitine * potent * apoptosis * subgroups * purines * abt-199
OECD category: Biochemistry and molecular biology
Impact factor: 6.205, year: 2019
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b00189
Permanent Link: http://hdl.handle.net/11104/0319083 - 3.0496501 - ÚEB 2019 RIV US eng J - Journal Article
Jorda, Radek - Hendrychová, Denisa - Voller, Jiří - Řezníčková, Eva - Gucký, Tomáš - Kryštof, Vladimír
How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases?
Journal of Medicinal Chemistry. Roč. 61, č. 20 (2018), s. 9105-9120. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) LO1204; GA ČR GA17-14007S
Institutional support: RVO:61389030
Keywords : small-molecule inhibitors * metastatic breast-cancer * 1st global approval * thermal shift assay * dna-damage response * in-vitro * androgen receptor * cdk inhibitors * highly potent * 2,6,9-trisubstituted purines
OECD category: Oncology
Impact factor: 6.054, year: 2018
Permanent Link: http://hdl.handle.net/11104/0289264File Download Size Commentary Version Access 2018_Jorda_JOURNAL OF MEDICINAL CHEMISTRY_9105.pdf 5 7.3 MB Other open-access - 4.0482957 - ÚEB 2018 RIV GB eng J - Journal Article
Malínková, Veronika - Řezníčková, Eva - Jorda, Radek - Gucký, T. - Kryštof, Vladimír
Trisubstituted purine inhibitors of PDGFR alpha and their antileukemic activity in the human eosinophilic cell line EOL-1.
Bioorganic & Medicinal Chemistry. Roč. 25, č. 24 (2017), s. 6523-6535. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA MŠMT(CZ) LO1204
Institutional support: RVO:61389030
Keywords : dependent kinase inhibitors * src tyrosine kinase * 2,6,9-trisubstituted purines * therapeutic target * potent inhibitor * imatinib * leukemia * mutations * mutant * domain
OECD category: Hematology
Impact factor: 2.881, year: 2017
Permanent Link: http://hdl.handle.net/11104/0278331File Download Size Commentary Version Access 2017_Malinkova_Bioorganic & medicinal chemistry_6523.pdf 1 1.1 MB Other open-access - 5.0471122 - ÚOCHB 2017 CZ eng A - Abstract
Sabat, Nazarii - Klečka, Martin - Hocek, Michal
Novel C-H activations of purines and deazapurines. Synthesis of substituted deazapurine nucleobases.
Liblice 2016. 51st Advances in Organic, Bioorganic and Pharmaceutical Chemistry. Praha: Czech Chemical Society, 2016. s. 44.
[Liblice 2016. Advances in Organic, Bioorganic and Pharmaceutical Chemistry /51./. 11.11.2016-13.11.2016, Lázně Bělohrad]
R&D Projects: GA ČR(CZ) GA16-00178S
Institutional support: RVO:61388963
Keywords : deazapurines * purines * nucleobase synthesis
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0268753 - 6.0445290 - ÚOCHB 2016 RIV DE eng J - Journal Article
Malnuit, Vincent - Poštová Slavětínská, Lenka - Nauš, Petr - Džubák, P. - Hajdúch, M. - Stolaříková, J. - Snášel, Jan - Pichová, Iva - Hocek, Michal
2-Substituted 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity.
ChemMedChem. Roč. 10, č. 6 (2015), s. 1079-1093. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA ČR GAP207/11/0344; GA MŠMT(CZ) LO1304; GA MŠMT LO1302; GA TA ČR(CZ) TE01020028
EU Projects: European Commission(XE) 241587 - SYSTEMTB
Institutional support: RVO:61388963
Keywords : antimycobacterial agents * cytostatics * nucleosides * purines * pyrrolopyrimidines
Subject RIV: CC - Organic Chemistry
Impact factor: 2.980, year: 2015
Permanent Link: http://hdl.handle.net/11104/0247636 - 7.0443135 - ÚOCHB 2016 RIV GB eng J - Journal Article
Dejmek, Milan - Šála, Michal - Hřebabecký, Hubert - Dračínský, Martin - Procházková, Eliška - Chalupská, Dominika - Klíma, Martin - Plačková, Pavla - Hájek, Miroslav - Andrei, G. - Naesens, L. - Leyssen, P. - Neyts, J. - Balzarini, J. - Bouřa, Evžen - Nencka, Radim
Norbornane-based nucleoside and nucleotide analogues locked in North conformation.
Bioorganic & Medicinal Chemistry. Roč. 23, č. 1 (2015), s. 184-191. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA ČR GPP207/12/P625; GA MŠMT LO1302
Institutional support: RVO:61388963
Keywords : carbocyclic nucleosides * purines * norbornane * antiviral * PI4KIIalpha
Subject RIV: CC - Organic Chemistry
Impact factor: 2.923, year: 2015
Permanent Link: http://hdl.handle.net/11104/0245898 - 8.0442424 - BFÚ 2015 RIV CH eng J - Journal Article
Sharma, V.K. - Jelen, František - Trnková, L.
Functionalized Solid Electrodes for Electrochemical Biosensing of Purine Nucleobases and Their Analogues: A Review.
Sensors. Roč. 15, č. 1 (2015), s. 1564-1600. E-ISSN 1424-8220
Institutional support: RVO:68081707
Keywords : purine derivatives * electrochemistry of purines * carbon electrode
Subject RIV: BO - Biophysics
Impact factor: 2.033, year: 2015
Permanent Link: http://hdl.handle.net/11104/0245239 - 9.0440605 - BFÚ 2015 RIV CS eng J - Journal Article
Navrátil, R. - Pilarová, I. - Jelen, František - Trnková, L.
Comparative Voltammetric Analysis of Adenine and Xanthine on a Pencil Graphite Electrode in the Presence of Copper Ions.
International Journal of Electrochemical Science. Roč. 8, č. 4 (2013), s. 4397-4408. ISSN 1452-3981. E-ISSN 1452-3981
R&D Projects: GA ČR GAP205/10/2378
Institutional support: RVO:68081707
Keywords : Oxidation of purines * Pencil graphite electrode * Linear sweep voltammetry
Subject RIV: BO - Biophysics
Impact factor: 1.956, year: 2013
Permanent Link: http://hdl.handle.net/11104/0243730 - 10.0430390 - ÚOCHB 2015 RIV DE eng J - Journal Article
Dejmek, Milan - Šála, Michal - Plačková, Pavla - Hřebabecký, Hubert - Borreda, L. M. - Neyts, J. - Dračínský, Martin - Procházková, Eliška - Jansa, Petr - Leyssen, P. - Mertlíková-Kaiserová, Helena - Nencka, Radim
Synthesis of Novel Purine-Based Coxsackievirus Inhibitors Bearing Polycylic Substituents at the N-9 Position.
Archiv der Pharmazie. Roč. 347, č. 7 (2014), s. 478-485. ISSN 0365-6233. E-ISSN 1521-4184
R&D Projects: GA ČR GAP303/11/1297
Institutional support: RVO:61388963
Keywords : antiviral * coxsackievirus B3 * enteroviruses * phosphatidylinositol 4-kinase (PI4K) * purines
Subject RIV: CC - Organic Chemistry
Impact factor: 1.531, year: 2014
Permanent Link: http://hdl.handle.net/11104/0235359