Search results
- 1.0576067 - ÚEB 2024 RIV cze P - Patent Document
Cankař, Petr - Tomanová, Monika - Jedinák, L. - Kryštof, Vladimír - Jorda, Radek - Řezníčková, Eva - Strnad, Miroslav
Substituované purinové sloučeniny jako inhibitory proteinkináz, jejich použití jako léčiva a farmaceutické přípravky obsahující tyto deriváty.
[Substituted purine compounds as protein kinase inhibitors, their use as medicaments and pharmaceutical preparations containing these derivatives.]
2022. Owner: Ústav experimentální botaniky AV ČR, v. v. i. Date of the patent acceptance: 17.08.2022. Patent Number: 309356. Territorial Protection: národní patent v členském státě EU .
Institutional support: RVO:61389030
Keywords : purines * purine alkylation * acyclic nucleosides
OECD category: Organic chemistry
https://isdv.upv.cz/doc/FullFiles/Patents/FullDocuments/309/309356.pdf
Permanent Link: https://hdl.handle.net/11104/0345691File Download Size Commentary Version Access 2022_Cankar_patent_CZ309356.pdf 2 1.1 MB Other open-access - 2.0567469 - ÚMG 2023 RIV CH eng J - Journal Article
Součková, O. - Škopová, V. - Barešová, V. - Sedlák, David - Bleyer, A. J. - Kmoch, S. - Zikánová, M.
Metabolites of De Novo Purine Synthesis: Metabolic Regulators and Cytotoxic Compounds.
Metabolites. Roč. 12, č. 12 (2022), č. článku 1210. E-ISSN 2218-1989
R&D Projects: GA MŠMT(CZ) LM2018130
Research Infrastructure: NCMG II - 90132
Institutional support: RVO:68378050
Keywords : purine synthesis * pfas * paics * adsl * atic * cytotoxicity * fgar * air * saicar * aicar
OECD category: Biochemistry and molecular biology
Impact factor: 4.1, year: 2022
Method of publishing: Open access
https://www.mdpi.com/2218-1989/12/12/1210
Permanent Link: https://hdl.handle.net/11104/0338718 - 3.0559918 - ÚOCHB 2023 RIV cze P - Patent Document
Skácel, Jan - Janeba, Zlatko - Mertlíková-Kaiserová, Helena
Inhibitory purinnukleosidfosforylasy, jejich příprava a použití k léčení T-buněčné akutní lymfoblastické leukémie a lymfomů.
[Purine nucleoside phosphorylase inhibitors, preparing them and use in treating T-cell acute lymphoblastic leukaemia and lymphomas.]
2022. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 31.03.2022. Patent Number: 309199
R&D Projects: GA TA ČR(CZ) TN01000013
Institutional support: RVO:61388963
Keywords : PNP * purine nucleoside phosphorylase * T-ALL
OECD category: Medicinal chemistry
https://isdv.upv.cz/doc/FullFiles/Patents/FullDocuments/309/309199.pdf
Permanent Link: https://hdl.handle.net/11104/0333043 - 4.0558477 - ÚFCH JH 2023 RIV CH eng J - Journal Article
Ferus, Martin - Knížek, Antonín - Petera, Lukáš - Pastorek, Adam - Hrnčířová, J. - Jankovič, L. - Ivanek, Ondřej - Šponer, Jiří - Křivková, Anna - Saeidfirozeh, Homa - Civiš, Svatopluk - Chatzitheodoridis, E. - Mráziková, Klaudia - Nejdl, L. - Saija, F. - Šponer, Judit E. - Cassone, G.
Formamide-Based Post-impact Thermal Prebiotic Synthesis in Simulated Craters: Intermediates, Products and Mechanism.
Frontiers in Astronomy and Space Sciences. Roč. 9, May 2022 (2022), č. článku 882145. E-ISSN 2296-987X
R&D Projects: GA ČR(CZ) GA21-11366S; GA MŠMT EF16_019/0000778
Institutional support: RVO:61388955 ; RVO:68081707
Keywords : high-energy chemistry * organic-molecules * gale crater * basis-sets * unified mechanism * hydrogen-cyanide * building-blocks * shock synthesis * purine ring * amino-acids * prebiotic chemistry * origin of life * formamide * FTIR spectroscopy * quantum-mechanical calculations * ab initio molecular dynamics * metadynamics
OECD category: Physical chemistry; Physical chemistry (BFU-R)
Impact factor: 3, year: 2022
Method of publishing: Open access
Permanent Link: http://hdl.handle.net/11104/0332124 - 5.0556977 - ÚOCHB 2023 RIV GB eng J - Journal Article
Knejzlík, Zdeněk - Doležal, Michal - Herkommerová, Klára - Clarová, Kamila - Klíma, Martin - Dedola, Matteo - Zborníková, Eva - Rejman, Dominik - Pichová, Iva
The mycobacterial guaB1 gene encodes a guanosine 5 '-monophosphate reductase with a cystathionine-beta-synthase domain.
FEBS Journal. Roč. 289, č. 18 (2022), s. 5571-5598. ISSN 1742-464X. E-ISSN 1742-4658
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : CBS domain * GMPR * guaB1 * Mycobacterium * purine biosynthesis
OECD category: Biochemistry and molecular biology
Impact factor: 5.4, year: 2022
Method of publishing: Open access
https://doi.org/10.1111/febs.16448
Permanent Link: http://hdl.handle.net/11104/0331102 - 6.0550914 - BC 2022 RIV GB eng J - Journal Article
Doleželová, Eva - Klejch, Tomáš - Špaček, Petr - Slapničková, Martina - Guddat, L. - Hocková, Dana - Zíková, Alena
Acyclic nucleoside phosphonates with adenine nucleobase inhibit Trypanosoma brucei adenine phosphoribosyltransferase in vitro.
Scientific Reports. Roč. 11, č. 1 (2021), č. článku 13317. ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA ČR(CZ) GA19-07707S; GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:60077344 ; RVO:61388963
Keywords : plasmodium-falciparum * 6-oxopurine phosphoribosyltransferases * antimalarial activity * crystal-structure * adenosine kinase * purine salvage * prodrugs * vivax * protein * bisphosphonates
OECD category: Microbiology; Organic chemistry (UOCHB-X)
Impact factor: 4.997, year: 2021
Method of publishing: Open access
https://www.nature.com/articles/s41598-021-91747-6
Permanent Link: http://hdl.handle.net/11104/0326211 - 7.0548632 - ÚIACH 2022 RIV CH eng J - Journal Article
Rouchal, M. - Rudolfová, J. - Kryštof, V. - Vojáčková, V. - Čmelík, Richard - Vícha, R.
Adamantane-Substituted Purines and Their β-Cyclodextrin Complexes: Synthesis and Biological Activity.
International Journal of Molecular Sciences. Roč. 22, č. 23 (2021), č. článku 12675. E-ISSN 1422-0067
Institutional support: RVO:68081715
Keywords : adamantane * 2,6,9-trisubstituted purine * molecular docking
OECD category: Analytical chemistry
Impact factor: 6.208, year: 2021
Method of publishing: Limited access
Permanent Link: http://hdl.handle.net/11104/0324667File Download Size Commentary Version Access 0548632.pdf 1 1.2 MB Publisher’s postprint require - 8.0547369 - ÚOCHB 2022 RIV AE eng J - Journal Article
Alt, J. - Gori, S. S. - Lemberg, K. M. - Pal, A. - Veeravalli, V. - Wu, Y. - Aguilar, J. M. H. - Dash, R. P. - Tenora, Lukáš - Majer, Pavel - Sun, Q. - Slusher, B. S. - Rais, R.
Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement.
Current Drug Metabolism. Roč. 22, č. 9 (2021), s. 735-745. ISSN 1389-2002. E-ISSN 1875-5453
R&D Projects: GA MŠMT LTAUSA18166
Institutional support: RVO:61388963
Keywords : Glutamine antagonist * purine synthesis * formylglycinamide ribonucleotide * formylglycinamidine ribonucleotide * biomarker * cancer * LC-MS
OECD category: Organic chemistry
Impact factor: 3.408, year: 2021
Method of publishing: Limited access
https://doi.org/10.2174/1389200222666210831125041
Permanent Link: http://hdl.handle.net/11104/0323608 - 9.0545555 - ÚOCHB 2022 RIV FR eng J - Journal Article
Kalčic, Filip - Frydrych, Jan - Doleželová, Eva - Slapničková, Martina - Pachl, Petr - Poštová Slavětínská, Lenka - Dračínský, Martin - Hocková, Dana - Zíková, Alena - Janeba, Zlatko
C1′-Branched acyclic nucleoside phosphonates mimicking adenosine monophosphate: Potent inhibitors of Trypanosoma brucei adenine phosphoribosyltransferase.
European Journal of Medicinal Chemistry. Roč. 225, Dec 5 (2021), č. článku 113798. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MŠMT(CZ) EF16_019/0000759; GA ČR(CZ) GA19-07707S
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : trypanosomiasis * purine salvage pathway * APRT * nucleotide analogues * phosphonates * enzyme inhibitors
OECD category: Organic chemistry; Microbiology (BC-A)
Impact factor: 7.088, year: 2021
Method of publishing: Limited access
https://doi.org/10.1016/j.ejmech.2021.113798
Permanent Link: http://hdl.handle.net/11104/0322237 - 10.0543635 - ÚFCH JH 2022 RIV US eng J - Journal Article
Zemánková, K. - Nejdl, L. - Bezděková, J. - Vodová, M. - Petera, Lukáš - Pastorek, Adam - Civiš, Svatopluk - Kubelík, Petr - Ferus, Martin - Adam, V. - Vaculovičová, M.
Micellar electrokinetic chromatography as a powerful analytical tool for research on prebiotic chemistry.
Microchemical Journal. Roč. 167, AUG 2021 (2021), č. článku 106022. ISSN 0026-265X. E-ISSN 1095-9149
R&D Projects: GA ČR GA19-03314S; GA MŠMT EF16_019/0000778
Institutional support: RVO:61388955
Keywords : high-energy chemistry * capillary-electrophoresis * rich atmospheres * hydrogen-cyanide * formamide * origin * purine * bases * nucleobases * adenine * Capillary electrophoresis * Purine * Pyrimidine * Nucleobases * Origin of life * Molecularly imprinted polymers
OECD category: Physical chemistry
Impact factor: 5.304, year: 2021
Method of publishing: Limited access
Permanent Link: http://hdl.handle.net/11104/0320824File Download Size Commentary Version Access 0543635.pdf 2 1 MB Publisher’s postprint require