Search results

  1. 1.
    0557115 - ÚOCHB 2023 RIV US eng J - Journal Article
    Markowicz-Piasecka, M. - Markiewicz, A. - Darlak, P. - Sikora, J. - Adla, Santosh Kumar - Bagina, S. - Huttunen, K. M.
    Current Chemical, Biological, and Physiological Views in the Development of Successful Brain-Targeted Pharmaceutics.
    Neurotherapeutics. (2022). ISSN 1933-7213. E-ISSN 1878-7479
    Institutional support: RVO:61388963
    Keywords : brain-blood barrier * prodrug approach * carrier-mediated transport * receptor-mediated transport * drug delivery
    OECD category: Biochemistry and molecular biology
    Impact factor: 7.620, year: 2020
    Method of publishing: Limited access
    https://doi.org/10.1007/s13311-022-01228-5
    Permanent Link: http://hdl.handle.net/11104/0331172
     
     
  2. 2.
    0554906 - BFÚ 2022 RIV US eng J - Journal Article
    Biancalana, L. - Kostrhunová, Hana - Batchelor, L. - Hadiji, M. - Degano, I. - Pampaloni, G. - Zacchini, S. - Dyson, P.J. - Brabec, Viktor - Marchetti, F.
    Hetero-Bis-Conjugation of Bioactive Molecules to Half-Sandwich Ruthenium(II) and Iridium(III) Complexes Provides Synergic Effects in Cancer Cell Cytotoxicity.
    Inorganic Chemistry. Roč. 60, č. 13 (2021), s. 9529-9541. ISSN 0020-1669. E-ISSN 1520-510X
    R&D Projects: GA ČR(CZ) GC20-14082J
    Institutional support: RVO:68081707
    Keywords : anticancer agents * platinum(iv) prodrug * crystal-structure * rational design * acid * derivatives
    OECD category: Organic chemistry
    Impact factor: 5.165, year: 2020
    Method of publishing: Limited access
    https://pubs.acs.org/doi/10.1021/acs.inorgchem.1c00641
    Permanent Link: http://hdl.handle.net/11104/0329521
     
     
  3. 3.
    0553286 - ÚOCHB 2023 RIV US eng J - Journal Article
    Khatun, M. - Kumar, K. - Baidya, A. - Mondal, P. K. - Baszczyňski, Ondřej - Kalčic, Filip - Banerjee, S. - Dhali, G. K. - Das, K. - Chowdhury, A. - Janeba, Zlatko - Chakrabarti, S. - Datta, S.
    Variability in the Responses of Hepatitis B Virus D-Subgenotypes to Antiviral Therapy: Designing Pan-D-Subgenotypic Reverse Transcriptase Inhibitors.
    Journal of Virology. Roč. 96, č. 2 (2022), č. článku e01800-21. ISSN 0022-538X. E-ISSN 1098-5514
    Institutional support: RVO:61388963
    Keywords : antiviral activity * entecavir * hepatitis B virus D-subgenotypes * high throughput virtual screening * phosphonate prodrug * zenofovir
    OECD category: Organic chemistry
    Impact factor: 5.103, year: 2020
    Method of publishing: Limited access
    https://doi.org/10.1128/JVI.01800-21
    Permanent Link: http://hdl.handle.net/11104/0328267
     
     
  4. 4.
    0552565 - ÚOCHB 2022 CZ eng A - Abstract
    Vrábel, Milan - Rahm, Michal
    New s-Tetrazines for Bioorthogonal Click-to-Release Chemistry.
    Liblice 2021. 55th Advances in Organic, Bioorganic and Pharmaceutical Chemistry. Praha: Czech Chemical Society, 2021. s. 178.
    [Liblice 2021. Advances in Organic, Bioorganic and Pharmaceutical Chemistry /55./. 03.11.2021-06.11.2021, Špindlerův Mlýn]
    Institutional support: RVO:61388963
    Keywords : click chemistry * bioorthogonal * prodrug release
    OECD category: Organic chemistry
    Permanent Link: http://hdl.handle.net/11104/0327673
     
     
  5. 5.
    0543389 - ÚOCHB 2022 RIV GB eng J - Journal Article
    Lášek, Tomáš - Dobiaš, Juraj - Buděšínský, Miloš - Kozák, Jaroslav - Lapuníková, Barbora - Rosenberg, Ivan - Birkuš, Gabriel - Páv, Ondřej
    Synthesis of phosphonate derivatives of 2′-deoxy-2′-fluorotetradialdose D-nucleosides and tetradialdose D-nucleosides.
    Tetrahedron. Roč. 89, Jun 4 (2021), č. článku 132159. ISSN 0040-4020. E-ISSN 1464-5416
    R&D Projects: GA MŠk(CZ) EF16_019/0000729
    Institutional support: RVO:61388963
    Keywords : nucleoside phosphonate * triphosphate * prodrug * tetradialdose d-nucleoside * 2′-fluoronucleoside
    OECD category: Organic chemistry
    Impact factor: 2.457, year: 2020
    Method of publishing: Limited access
    https://doi.org/10.1016/j.tet.2021.132159
    Permanent Link: http://hdl.handle.net/11104/0320603
     
     
  6. 6.
    0542010 - ÚOCHB 2022 RIV FR eng J - Journal Article
    Frydrych, Jan - Keough, D. T. - Chavchich, M. - Travis, J. - Dračínský, Martin - Edstein, M. D. - Guddat, L. W. - Hocková, Dana - Janeba, Zlatko
    Nucleotide analogues containing a pyrrolidine, piperidine or piperazine ring: Synthesis and evaluation of inhibition of plasmodial and human 6-oxopurine phosphoribosyltransferases and in vitro antimalarial activity.
    European Journal of Medicinal Chemistry. Roč. 219, Jul 5 (2021), č. článku 113416. ISSN 0223-5234. E-ISSN 1768-3254
    R&D Projects: GA ČR(CZ) GA19-07707S
    Institutional support: RVO:61388963
    Keywords : nucleoside phosphonates * phosphoroamidate prodrug * HG(X)PRT * hypoxanthine-guanine-(xanthine) phosphoribosyltransferase * Plasmodium falciparum * Plasmodium vivax
    OECD category: Organic chemistry
    Impact factor: 6.514, year: 2020
    Method of publishing: Limited access
    https://doi.org/10.1016/j.ejmech.2021.113416
    Permanent Link: http://hdl.handle.net/11104/0319509
     
     
  7. 7.
    0538814 - ÚOCHB 2022 RIV US eng J - Journal Article
    Dzijak, Rastislav - Galeta, Juraj - Vázquez, Arcadio - Kozák, Jaroslav - Matoušová, Marika - Fulka, Helena - Dračínský, Martin - Vrábel, Milan
    Structurally Redesigned Bioorthogonal Reagents for Mitochondria-Specific Prodrug Activation.
    JACS Au. Roč. 1, č. 1 (2021), s. 23-30. E-ISSN 2691-3704
    R&D Projects: GA ČR(CZ) GA19-13811S
    EU Projects: European Commission(XE) 677465 - SWEETOOLS
    Institutional support: RVO:61388963 ; RVO:68378041
    Keywords : bioorthogonal reactions * click-to-release * mitochondria * prodrug activation * tetrazines
    OECD category: Organic chemistry; Medicinal chemistry (UEM-P)
    Method of publishing: Open access
    https://doi.org/10.1021/jacsau.0c00053
    Permanent Link: http://hdl.handle.net/11104/0316967
     
     
  8. 8.
    0532238 - ÚMCH 2021 RIV DE eng J - Journal Article
    Geri, S. - Krunclová, Tereza - Janoušková, Olga - Pánek, Jiří - Hrubý, Martin - Hernández-Valdés, D. - Probst, B. - Alberto, R. A. - Mamat, C. - Kubeil, M. - Stephan, H.
    Light‐activated carbon monoxide prodrugs based on bipyridyl dicarbonyl ruthenium(II) complexes.
    Chemistry - A European Journal. Roč. 26, č. 48, SI (2020), s. 10992-11006. ISSN 0947-6539. E-ISSN 1521-3765
    R&D Projects: GA ČR(CZ) GA19-01438S
    Grant - others: AV ČR(CZ) DAAD-19-09
    Program: Bilaterální spolupráce
    Institutional support: RVO:61389013
    Keywords : carbon monoxide * prodrug * light activation
    OECD category: Polymer science
    Impact factor: 5.236, year: 2020
    Method of publishing: Open access
    https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/chem.202002139
    Permanent Link: http://hdl.handle.net/11104/0310928
     
     
  9. 9.
    0531699 - ÚOCHB 2021 RIV eng P - Patent Document
    Slusher, B. - Rais, R. - Krečmerová, Marcela - Tichý, Tomáš - Majer, Pavel - Jančařík, Andrej
    Prodrugs of prostate specific membrane antigen (PSMA) inhibitor.
    2020. Owner: The Johns Hopkins University - Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 28.01.2020. Patent Number: US10544176
    Institutional support: RVO:61388963
    Keywords : 2-Phosphonomethylpentanedioic acid (2-PMPA) * glutamate carboxypeptidase II * GCPII * PSMA * pivaloyloxymethyl * isopropyloxycarbonyloxymethyl * POM * POC * prodrug
    OECD category: Organic chemistry
    https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=US&NR=10544176B2&KC=B2&FT=D&ND=4&date=20200128&DB=&locale=en_EP
    Permanent Link: http://hdl.handle.net/11104/0310314
     
     
  10. 10.
    0519335 - ÚOCHB 2021 RIV GB eng J - Journal Article
    Procházková, Eliška - Hřebabecký, Hubert - Dejmek, Milan - Šála, Michal - Šmídková, Markéta - Tloušťová, Eva - Zborníková, Eva - Eyer, Luděk - Růžek, Daniel - Nencka, Radim
    Could 5′-N and S ProTide analogues work as prodrugs of antiviral agents?
    Bioorganic and Medicinal Chemistry Letters. Roč. 30, č. 4 (2020), č. článku 126897. ISSN 0960-894X. E-ISSN 1464-3405
    R&D Projects: GA MZd(CZ) NV16-34238A; GA MŠk(CZ) EF16_019/0000729; GA MŠk LO1302
    Institutional support: RVO:61388963 ; RVO:60077344
    Keywords : antiviral * nucleotide * prodrug * ProTide * HCV * 31P NMR spectroscopy
    OECD category: Organic chemistry; Microbiology (BC-A)
    Impact factor: 2.823, year: 2020
    Method of publishing: Limited access
    https://www.sciencedirect.com/science/article/pii/S0960894X19308753?via%3Dihub
    Permanent Link: http://hdl.handle.net/11104/0304523