Search results
- 1.0580663 - ÚOCHB 2024 RIV jpn P - Patent Document
Slusher, B. - Rais, R. - Majer, Pavel - Tenora, Lukáš - Novotná, Kateřina - Alt, J.
新規なグルタミンアンタゴニストおよびそれらの使用.
[Novel glutamine antagonists and uses thereof.]
2023. Owner: The Johns Hopkins University - Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 10.10.2023. Patent Number: JP7358342. Territorial Protection: národní patent v zemi mimo EU ,mezinárodní patentová ochrana dle Smlouvy o patentové spolupráci.
R&D Projects: GA MŠMT LTAUSA18166
Institutional support: RVO:61388963
Keywords : glutamine antagonists * 6-diazo-5-oxo-L-norleucine * prodrug strategies
OECD category: Organic chemistry
https://worldwide.espacenet.com/patent/search/family/065994832/publication/JP7358342B2?q=JP7358342B2
Permanent Link: https://hdl.handle.net/11104/0349426 - 2.0580592 - ÚOCHB 2024 RIV eng P - Patent Document
Slusher, B. - Rais, R. - Majer, Pavel - Tenora, Lukáš - Novotná, Kateřina - Alt, J.
Novel glutamine antagonists and uses thereof.
2022. Owner: The Johns Hopkins University - Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 24.08.2022. Patent Number: EP3692015. Territorial Protection: evropský patent podle Evropské patentové úmluvy ,mezinárodní patentová ochrana dle Smlouvy o patentové spolupráci.
R&D Projects: GA MŠMT LTAUSA18166
Institutional support: RVO:61388963
Keywords : glutamine antagonists * 6-diazo-5-oxo-L-norleucine * prodrug strategies
OECD category: Organic chemistry
https://worldwide.espacenet.com/patent/search/family/065994832/publication/EP3692015B1?q=EP3692015B1
Permanent Link: https://hdl.handle.net/11104/0349359 - 3.0580041 - ÚOCHB 2024 RIV eng P - Patent Document
Slusher, B. - Rais, R. - Riggins, G. - Majer, Pavel - Tichý, Tomáš - Vávra, Jan - Jančařík, Andrej - Tenora, Lukáš
Mebendazole prodrugs with enhanced solubility and oral bioavailability.
2023. Owner: The Johns Hopkins University - Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 14.09.2023. Patent Number: AU2019216757. Territorial Protection: národní patent v zemi mimo EU ,mezinárodní patentová ochrana dle Smlouvy o patentové spolupráci.
Institutional support: RVO:61388963
Keywords : mebendazole * prodrug * oral bioavailability
OECD category: Medicinal chemistry
https://worldwide.espacenet.com/patent/search/family/067549070/publication/AU2019216757B2?q=AU2019216757B2
Permanent Link: https://hdl.handle.net/11104/0348822 - 4.0577575 - ÚOCHB 2024 RIV eng P - Patent Document
Slusher, B. - Rais, R. - Riggins, G. - Majer, Pavel - Tichý, Tomáš - Vávra, Jan - Jančařík, Andrej - Tenora, Lukáš
Mebendazole prodrugs with enhanced solubility and oral bioavailability.
2023. Owner: The Johns Hopkins University - Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 01.08.2023. Patent Number: US11712435. Territorial Protection: národní patent v zemi mimo EU ,mezinárodní patentová ochrana dle Smlouvy o patentové spolupráci.
Institutional support: RVO:61388963
Keywords : mebendazole * prodrug * oral bioavailability
OECD category: Medicinal chemistry
https://worldwide.espacenet.com/patent/search/family/067549070/publication/US11712435B2?q=US11712435B2
Permanent Link: https://hdl.handle.net/11104/0346694 - 5.0568134 - ÚOCHB 2024 RIV GB eng J - Journal Article
Tsai, J. - Gori, S. - Alt, J. - Tiwari, S. - Iyer, J. - Talwar, R. - Hinsu, D. - Ahirwar, K. - Mohanty, S. - Khunt, C. - Sutariya, B. - Jani, K. - Venkatasubbaiah, V. - Patel, A. - Meghapara, J. - Joshi, K. - Sahu, R. - Rana, V. - Nigade, P. - Talluri, R. S. - Murty, K. V. S. N. - Joshi, K. - Ramanathan, V. - Li, A. - Islam, N. - Šnajdr, Ivan - Majer, Pavel - Rais, R. - Slusher, B. S. - Garza, L. A.
Topical SCD-153, a 4-methyl itaconate prodrug, for the treatment of alopecia areata.
PNAS Nexus. Roč. 2, č. 1 (2023), č. článku pgac297. E-ISSN 2752-6542
Institutional support: RVO:61388963
Keywords : alopecia areata * hair growth * topical * itaconate * prodrug * inflammation * immunosuppression * cytokine * interleukin * interferon * double-stranded RNA * polyinosinic–polycytidylic acid * hair cycle * anagen * telogen * keratinocyte * stability * pharmacokinetics * cytotoxicity
OECD category: Medicinal chemistry
Method of publishing: Open access
https://doi.org/10.1093/pnasnexus/pgac297
Permanent Link: https://hdl.handle.net/11104/0339488
Research data: Mendeley Data - 6.0559889 - ÚOCHB 2023 RIV eng P - Patent Document
Slusher, B. - Rais, R. - Krečmerová, Marcela - Tichý, Tomáš - Majer, Pavel - Jančařík, Andrej
Prodrugs of prostate specific membrane antigen (PSMA) inhibitor.
2022. Owner: The Johns Hopkins University - Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 10.05.2022. Patent Number: US11325931
Institutional support: RVO:61388963
Keywords : 2-Phosphonomethylpentanedioic acid (2-PMPA) * glutamate carboxypeptidase II * GCPII * PSMA * pivaloyloxymethyl * isopropyloxycarbonyloxymethyl * POM * POC * prodrug
OECD category: Organic chemistry
https://worldwide.espacenet.com/patent/search/family/055264571/publication/US11325931B2?q=US11325931B2
Permanent Link: https://hdl.handle.net/11104/0333018 - 7.0559886 - ÚOCHB 2023 RIV eng P - Patent Document
Slusher, B. - Rais, R. - Krečmerová, Marcela - Tichý, Tomáš - Majer, Pavel - Jančařík, Andrej
Prodrugs of prostate specific membrane antigen (PSMA) inhibitor.
2022. Owner: The Johns Hopkins University - Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 12.01.2022. Patent Number: EP3177632
Institutional support: RVO:61388963
Keywords : 2-Phosphonomethylpentanedioic acid (2-PMPA) * glutamate carboxypeptidase II * GCPII * PSMA * pivaloyloxymethyl * isopropyloxycarbonyloxymethyl * POM * POC * prodrug
OECD category: Organic chemistry
https://worldwide.espacenet.com/patent/search/family/055264571/publication/EP3177632B1?q=EP3177632B1
Permanent Link: https://hdl.handle.net/11104/0333015 - 8.0557115 - ÚOCHB 2023 RIV US eng J - Journal Article
Markowicz-Piasecka, M. - Markiewicz, A. - Darlak, P. - Sikora, J. - Adla, Santosh Kumar - Bagina, S. - Huttunen, K. M.
Current Chemical, Biological, and Physiological Views in the Development of Successful Brain-Targeted Pharmaceutics.
Neurotherapeutics. Roč. 19, č. 3 (2022), s. 942-976. ISSN 1933-7213. E-ISSN 1878-7479
Institutional support: RVO:61388963
Keywords : brain-blood barrier * prodrug approach * carrier-mediated transport * receptor-mediated transport * drug delivery
OECD category: Biochemistry and molecular biology
Impact factor: 5.7, year: 2022
Method of publishing: Limited access
https://doi.org/10.1007/s13311-022-01228-5
Permanent Link: http://hdl.handle.net/11104/0331172 - 9.0554906 - BFÚ 2022 RIV US eng J - Journal Article
Biancalana, L. - Kostrhunová, Hana - Batchelor, L. - Hadiji, M. - Degano, I. - Pampaloni, G. - Zacchini, S. - Dyson, P.J. - Brabec, Viktor - Marchetti, F.
Hetero-Bis-Conjugation of Bioactive Molecules to Half-Sandwich Ruthenium(II) and Iridium(III) Complexes Provides Synergic Effects in Cancer Cell Cytotoxicity.
Inorganic Chemistry. Roč. 60, č. 13 (2021), s. 9529-9541. ISSN 0020-1669. E-ISSN 1520-510X
R&D Projects: GA ČR(CZ) GC20-14082J
Institutional support: RVO:68081707
Keywords : anticancer agents * platinum(iv) prodrug * crystal-structure * rational design * acid * derivatives
OECD category: Organic chemistry
Impact factor: 5.436, year: 2021
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.inorgchem.1c00641
Permanent Link: http://hdl.handle.net/11104/0329521 - 10.0553286 - ÚOCHB 2023 RIV US eng J - Journal Article
Khatun, M. - Kumar, K. - Baidya, A. - Mondal, R. K. - Baszczyňski, Ondřej - Kalčic, Filip - Banerjee, S. - Dhali, G. K. - Das, K. - Chowdhury, A. - Janeba, Zlatko - Chakrabarti, S. - Datta, S.
Variability in the Responses of Hepatitis B Virus D-Subgenotypes to Antiviral Therapy: Designing Pan-D-Subgenotypic Reverse Transcriptase Inhibitors.
Journal of Virology. Roč. 96, č. 2 (2022), č. článku e01800-21. ISSN 0022-538X. E-ISSN 1098-5514
Institutional support: RVO:61388963
Keywords : antiviral activity * entecavir * hepatitis B virus D-subgenotypes * high throughput virtual screening * phosphonate prodrug * zenofovir
OECD category: Organic chemistry
Impact factor: 5.4, year: 2022
Method of publishing: Limited access
https://doi.org/10.1128/JVI.01800-21
Permanent Link: http://hdl.handle.net/11104/0328267