Search results
- 1.0568134 - ÚOCHB 2024 RIV GB eng J - Journal Article
Tsai, J. - Gori, S. - Alt, J. - Tiwari, S. - Iyer, J. - Talwar, R. - Hinsu, D. - Ahirwar, K. - Mohanty, S. - Khunt, C. - Sutariya, B. - Jani, K. - Vankatasubbaiah, V. - Patel, A. - Meghapara, J. - Joshi, K. - Sahu, R. - Rana, V. - Nigade, P. - Talluri, R. S. - Murty, K. V. S. N. - Joshi, K. - Ramanathan, V. - Li, A. - Islam, N. - Šnajdr, Ivan - Majer, Pavel - Rais, R. - Slusher, B. S. - Garza, L. A.
Topical SCD-153, a 4-methyl itaconate prodrug, for the treatment of alopecia areata.
PNAS Nexus. Roč. 2, č. 1 (2023), č. článku pgac297. E-ISSN 2752-6542
Institutional support: RVO:61388963
Keywords : alopecia areata * hair growth * topical * itaconate * prodrug * inflammation * immunosuppression * cytokine * interleukin * interferon * double-stranded RNA * polyinosinic–polycytidylic acid * hair cycle * anagen * telogen * keratinocyte * stability * pharmacokinetics * cytotoxicity
Method of publishing: Open access
https://doi.org/10.1093/pnasnexus/pgac297
Permanent Link: https://hdl.handle.net/11104/0339488
- 2.0559889 - ÚOCHB 2023 RIV eng P - Patent Document
Slusher, B. - Rais, R. - Krečmerová, Marcela - Tichý, Tomáš - Majer, Pavel - Jančařík, Andrej
Prodrugs of prostate specific membrane antigen (PSMA) inhibitor.
2022. Owner: The Johns Hopkins University - Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 10.05.2022. Patent Number: US11325931
Institutional support: RVO:61388963
Keywords : 2-Phosphonomethylpentanedioic acid (2-PMPA) * glutamate carboxypeptidase II * GCPII * PSMA * pivaloyloxymethyl * isopropyloxycarbonyloxymethyl * POM * POC * prodrug
OECD category: Organic chemistry
https://worldwide.espacenet.com/patent/search/family/055264571/publication/US11325931B2?q=US11325931B2
Permanent Link: https://hdl.handle.net/11104/0333018
- 3.0559886 - ÚOCHB 2023 RIV eng P - Patent Document
Slusher, B. - Rais, R. - Krečmerová, Marcela - Tichý, Tomáš - Majer, Pavel - Jančařík, Andrej
Prodrugs of prostate specific membrane antigen (PSMA) inhibitor.
2022. Owner: The Johns Hopkins University - Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 12.01.2022. Patent Number: EP3177632
Institutional support: RVO:61388963
Keywords : 2-Phosphonomethylpentanedioic acid (2-PMPA) * glutamate carboxypeptidase II * GCPII * PSMA * pivaloyloxymethyl * isopropyloxycarbonyloxymethyl * POM * POC * prodrug
OECD category: Organic chemistry
https://worldwide.espacenet.com/patent/search/family/055264571/publication/EP3177632B1?q=EP3177632B1
Permanent Link: https://hdl.handle.net/11104/0333015
- 4.0557115 - ÚOCHB 2023 RIV US eng J - Journal Article
Markowicz-Piasecka, M. - Markiewicz, A. - Darlak, P. - Sikora, J. - Adla, Santosh Kumar - Bagina, S. - Huttunen, K. M.
Current Chemical, Biological, and Physiological Views in the Development of Successful Brain-Targeted Pharmaceutics.
Neurotherapeutics. Roč. 19, č. 3 (2022), s. 942-976. ISSN 1933-7213. E-ISSN 1878-7479
Institutional support: RVO:61388963
Keywords : brain-blood barrier * prodrug approach * carrier-mediated transport * receptor-mediated transport * drug delivery
OECD category: Biochemistry and molecular biology
Impact factor: 6.088, year: 2021
Method of publishing: Limited access
https://doi.org/10.1007/s13311-022-01228-5
Permanent Link: http://hdl.handle.net/11104/0331172
- 5.0554906 - BFÚ 2022 RIV US eng J - Journal Article
Biancalana, L. - Kostrhunová, Hana - Batchelor, L. - Hadiji, M. - Degano, I. - Pampaloni, G. - Zacchini, S. - Dyson, P.J. - Brabec, Viktor - Marchetti, F.
Hetero-Bis-Conjugation of Bioactive Molecules to Half-Sandwich Ruthenium(II) and Iridium(III) Complexes Provides Synergic Effects in Cancer Cell Cytotoxicity.
Inorganic Chemistry. Roč. 60, č. 13 (2021), s. 9529-9541. ISSN 0020-1669. E-ISSN 1520-510X
R&D Projects: GA ČR(CZ) GC20-14082J
Institutional support: RVO:68081707
Keywords : anticancer agents * platinum(iv) prodrug * crystal-structure * rational design * acid * derivatives
OECD category: Organic chemistry
Impact factor: 5.436, year: 2021
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.inorgchem.1c00641
Permanent Link: http://hdl.handle.net/11104/0329521
- 6.0553286 - ÚOCHB 2023 RIV US eng J - Journal Article
Khatun, M. - Kumar, K. - Baidya, A. - Mondal, R. K. - Baszczyňski, Ondřej - Kalčic, Filip - Banerjee, S. - Dhali, G. K. - Das, K. - Chowdhury, A. - Janeba, Zlatko - Chakrabarti, S. - Datta, S.
Variability in the Responses of Hepatitis B Virus D-Subgenotypes to Antiviral Therapy: Designing Pan-D-Subgenotypic Reverse Transcriptase Inhibitors.
Journal of Virology. Roč. 96, č. 2 (2022), č. článku e01800-21. ISSN 0022-538X. E-ISSN 1098-5514
Institutional support: RVO:61388963
Keywords : antiviral activity * entecavir * hepatitis B virus D-subgenotypes * high throughput virtual screening * phosphonate prodrug * zenofovir
OECD category: Organic chemistry
Impact factor: 6.549, year: 2021
Method of publishing: Limited access
https://doi.org/10.1128/JVI.01800-21
Permanent Link: http://hdl.handle.net/11104/0328267
- 7.0552565 - ÚOCHB 2022 CZ eng A - Abstract
Vrábel, Milan - Rahm, Michal
New s-Tetrazines for Bioorthogonal Click-to-Release Chemistry.
Liblice 2021. 55th Advances in Organic, Bioorganic and Pharmaceutical Chemistry. Praha: Czech Chemical Society, 2021. s. 178.
[Liblice 2021. Advances in Organic, Bioorganic and Pharmaceutical Chemistry /55./. 03.11.2021-06.11.2021, Špindlerův Mlýn]
Institutional support: RVO:61388963
Keywords : click chemistry * bioorthogonal * prodrug release
OECD category: Organic chemistry
Permanent Link: http://hdl.handle.net/11104/0327673
- 8.0543389 - ÚOCHB 2022 RIV GB eng J - Journal Article
Lášek, Tomáš - Dobiaš, Juraj - Buděšínský, Miloš - Kozák, Jaroslav - Lapuníková, Barbora - Rosenberg, Ivan - Birkuš, Gabriel - Páv, Ondřej
Synthesis of phosphonate derivatives of 2′-deoxy-2′-fluorotetradialdose D-nucleosides and tetradialdose D-nucleosides.
Tetrahedron. Roč. 89, Jun 4 (2021), č. článku 132159. ISSN 0040-4020. E-ISSN 1464-5416
R&D Projects: GA MŠk(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : nucleoside phosphonate * triphosphate * prodrug * tetradialdose d-nucleoside * 2′-fluoronucleoside
OECD category: Organic chemistry
Impact factor: 2.388, year: 2021
Method of publishing: Limited access
https://doi.org/10.1016/j.tet.2021.132159
Permanent Link: http://hdl.handle.net/11104/0320603
- 9.0542010 - ÚOCHB 2022 RIV FR eng J - Journal Article
Frydrych, Jan - Keough, D. T. - Chavchich, M. - Travis, J. - Dračínský, Martin - Edstein, M. D. - Guddat, L. W. - Hocková, Dana - Janeba, Zlatko
Nucleotide analogues containing a pyrrolidine, piperidine or piperazine ring: Synthesis and evaluation of inhibition of plasmodial and human 6-oxopurine phosphoribosyltransferases and in vitro antimalarial activity.
European Journal of Medicinal Chemistry. Roč. 219, Jul 5 (2021), č. článku 113416. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA ČR(CZ) GA19-07707S
Institutional support: RVO:61388963
Keywords : nucleoside phosphonates * phosphoroamidate prodrug * HG(X)PRT * hypoxanthine-guanine-(xanthine) phosphoribosyltransferase * Plasmodium falciparum * Plasmodium vivax
OECD category: Organic chemistry
Impact factor: 7.088, year: 2021
Method of publishing: Limited access
https://doi.org/10.1016/j.ejmech.2021.113416
Permanent Link: http://hdl.handle.net/11104/0319509
- 10.0538814 - ÚOCHB 2022 RIV US eng J - Journal Article
Dzijak, Rastislav - Galeta, Juraj - Vázquez, Arcadio - Kozák, Jaroslav - Matoušová, Marika - Fulka, Helena - Dračínský, Martin - Vrábel, Milan
Structurally Redesigned Bioorthogonal Reagents for Mitochondria-Specific Prodrug Activation.
JACS Au. Roč. 1, č. 1 (2021), s. 23-30. E-ISSN 2691-3704
R&D Projects: GA ČR(CZ) GA19-13811S
EU Projects: European Commission(XE) 677465 - SWEETOOLS
Institutional support: RVO:61388963 ; RVO:68378041
Keywords : bioorthogonal reactions * click-to-release * mitochondria * prodrug activation * tetrazines
OECD category: Organic chemistry; Medicinal chemistry (UEM-P)
Method of publishing: Open access
https://doi.org/10.1021/jacsau.0c00053
Permanent Link: http://hdl.handle.net/11104/0316967